电解槽项目可行性报告目录.docx
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1、箨(扙搀瀀扻扙讀缁択頀h栀$TM5441 _PAI-1 抑制剂 - MedChemExpress.pdfpic1.gifTM5441_PAI-1抑制剂-MedChemExpress.pdf2019-1025bb96b51e-b79b-4fbc-92a9-bf8d61fb2653RUIGe35EiQ2m/yLt/5sGEWsUCRe87aWOoIzMwgLRD3c0P+DpXcPSpQ=TM5441,_PAI-1,抑制剂,MedChemExpress,_PAI4c83d0554e9d40bf228fa7e5334e53b1Hotline: 400-820-3792 InhibitorsAgoni
2、stsScreening Libraries www.MedChemE TM5441 Cat. No.:HY-101761 CAS No.:1190221-43-2 分式:CHClNO 分量:428.82 作靶点:PAI-1; Apoptosis 作通路:Metabolic Enzyme/Protease; Apoptosis 储存式:-20C3 yearsPowder 4C2 years -80C6 monthsIn solvent -20C1 month 溶解性数据 体外实验DMSO : 300 mg/mL (699.59 mM) * “ means soluble, but satura
3、tion unknown. Mass Solvent Concentration 1 mg5 mg10 mg 1 mM2.3320 mL11.6599 mL23.3198 mL 5 mM0.4664 mL2.3320 mL4.6640 mL 10 mM0.2332 mL1.1660 mL2.3320 mL 制备储备液 请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液,并请注意储备液的保存式和期限。 体内实验 请根据您的实验动物和给药式选择适当的溶解案,配制前请先配制澄清的储备液,再依次添加助溶剂 (为保证实验结果的可靠性,体内实验的作液,建议您现现配,当天使;澄清的储备液可以根据储存条
4、 件,适当保存;以下溶剂前的百分是指该溶剂在您配制终溶液中的体积占): 1. 请依序添加每种溶剂: 10% DMSO 40% PEG300 5% Tween-80 45% saline Solubility: 2.5 mg/mL (5.83 mM); Clear solution 2. 请依序添加每种溶剂: 10% DMSO 90% corn oil Solubility: 2.5 mg/mL (5.83 mM); Clear solution 1/2Master of Small Molecules 您边的抑制剂师 www.MedChemE BIOLOGICAL ACTIVITY 物活性 T
5、M5441 是种服物可利的纤溶酶原激活物抑制剂-1 抑制剂 (PAI-1),抑制多个癌症细胞系的IC50 值在 13.9 到 51.1 M,并诱导种类癌症细胞的内在调亡。TM5441 减弱 N-硝基-1-精氨酸甲酯诱导的脏 压和管衰 1 2。 IC50 10(7):e0133786. 2. Jeong BY, et al. Novel Plasminogen Activator Inhibitor-1 Inhibitors Prevent Diabetic Kidney Injury in a Mouse Model. PLoS One. 2016 Jun 3;11(6):e0157012.
6、McePdfHeight Caution: Product has not been fully validated for medical applications. For research use only. Tel: 400-820-3792; 021-58955995 Fax: 021-53700325 E-mail: techMedChemE 2/2Master of Small Molecules 您边的抑制剂师 MedChemExpress0001200001可研报告20191025090855008708/pagfsCYtzJ9EUM/Pt/Dkjh/L+ilE3n/SoED
7、cjpOrVAFOylrWu2W3AIcr3J880vuT箨(退扦搀瀀扻退扦讀缁択銰頀h谀栀$TMC353121 _RSV 抑制剂 - MedChemExpress.pdfpic1.gifTMC353121_RSV抑制剂-MedChemExpress.pdf2019-102531498955-115f-442d-b618-bb25b728fd87ItHYuglBHuKpzVZc7KO1gOuv1kUWt6oZwWazdfpUlfz1Kz0EcyBfrQ=TMC353121,_RSV,抑制剂,MedChemExpress6d3bfb443daf9726dd3087aaea06d970Hotlin
8、e: 400-820-3792 InhibitorsAgonistsScreening Libraries www.MedChemE TMC353121 Cat. No.:HY-11097 CAS No.:857066-90-1 分式:CHNO 分量:558.71 作靶点:RSV 作通路:Anti-infection 储存式:-20C3 yearsPowder 4C2 years -80C6 monthsIn solvent -20C1 month 溶解性数据 体外实验DMSO : 50 mg/mL (89.49 mM; Need ultrasonic) H2O : 40% PEG300 5%
9、 Tween-80 45% saline Solubility: 2.5 mg/mL (4.47 mM); Clear solution 2. 请依序添加每种溶剂: 10% DMSO 90% (20% SBE-CD in saline) Solubility: 2.5 mg/mL (4.47 mM); Suspended solution; Need ultrasonic 3. 请依序添加每种溶剂: 10% DMSO 90% corn oil 体内实验 1/3Master of Small Molecules 您边的抑制剂师 www.MedChemE Solubility: 2.5 mg/mL
10、 (4.47 mM); Clear solution BIOLOGICAL ACTIVITY 物活性 TMC353121 是种有效的呼吸道合胞病毒 (RSV) 融合抑制剂,pEC50 为 9.9。 IC50 73(7):1823-1829. See more customer validations on www.MedChemE REFERENCES 1. Bonfanti JF, et al. Selection of a respiratory syncytial virus fusion inhibitor clinical candidate. 2. Discovery of a m
11、orpholinopropylaminobenzimidazole derivative (TMC353121). J Med Chem. 2008 Feb 28;51(4):875-96. 2. Rouan MC, et al. Pharmacokinetics-pharmacodynamics of a respiratory syncytial virus fusion inhibitor in the cotton rat model. Antimicrob Agents Chemother. 2010 Nov;54(11):4534-9. 3. Olszewska W, et al.
12、 Antiviral and lung protective activity of a novel respiratory syncytial virus fusion inhibitor in a mouse model. Eur Respir J. 2011 Aug;38(2):401-8. McePdfHeight Caution: Product has not been fully validated for medical applications. For research use only. Tel: 400-820-3792; 021-58955995 Fax: 021-5
13、3700325 E-mail: techMedChemE 3/3Master of Small Molecules 您边的抑制剂师 MedChemExpress0001200001可研报告20191025090857579877CSvL30NRTG+gHJNMR7aP/DBpO+BR+9362m+d18X/PIUhWwp8mw21QPUuC8nEq99lT玃耀蹞0藡箨(扙搀瀀扻扙讀缁択頀h栀$TM5441 _PAI-1 抑制剂 - MedChemExpress.pdfpic1.gifTM5441_PAI-1抑制剂-MedChemExpress.pdf2019-1025bb96b51e-b79b
14、-4fbc-92a9-bf8d61fb2653RUIGe35EiQ2m/yLt/5sGEWsUCRe87aWOoIzMwgLRD3c0P+DpXcPSpQ=TM5441,_PAI-1,抑制剂,MedChemExpress,_PAI4c83d0554e9d40bf228fa7e5334e53b1Hotline: 400-820-3792 InhibitorsAgonistsScreening Libraries www.MedChemE TM5441 Cat. No.:HY-101761 CAS No.:1190221-43-2 分式:CHClNO 分量:428.82 作靶点:PAI-1; Ap
15、optosis 作通路:Metabolic Enzyme/Protease; Apoptosis 储存式:-20C3 yearsPowder 4C2 years -80C6 monthsIn solvent -20C1 month 溶解性数据 体外实验DMSO : 300 mg/mL (699.59 mM) * “ means soluble, but saturation unknown. Mass Solvent Concentration 1 mg5 mg10 mg 1 mM2.3320 mL11.6599 mL23.3198 mL 5 mM0.4664 mL2.3320 mL4.664
16、0 mL 10 mM0.2332 mL1.1660 mL2.3320 mL 制备储备液 请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液,并请注意储备液的保存式和期限。 体内实验 请根据您的实验动物和给药式选择适当的溶解案,配制前请先配制澄清的储备液,再依次添加助溶剂 (为保证实验结果的可靠性,体内实验的作液,建议您现现配,当天使;澄清的储备液可以根据储存条 件,适当保存;以下溶剂前的百分是指该溶剂在您配制终溶液中的体积占): 1. 请依序添加每种溶剂: 10% DMSO 40% PEG300 5% Tween-80 45% saline Solubility: 2.5 mg/mL (
17、5.83 mM); Clear solution 2. 请依序添加每种溶剂: 10% DMSO 90% corn oil Solubility: 2.5 mg/mL (5.83 mM); Clear solution 1/2Master of Small Molecules 您边的抑制剂师 www.MedChemE BIOLOGICAL ACTIVITY 物活性 TM5441 是种服物可利的纤溶酶原激活物抑制剂-1 抑制剂 (PAI-1),抑制多个癌症细胞系的IC50 值在 13.9 到 51.1 M,并诱导种类癌症细胞的内在调亡。TM5441 减弱 N-硝基-1-精氨酸甲酯诱导的脏 压和管衰
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