LDN-212854-DataSheet-MedChemExpress.pdf
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1、LDN-212854Cat. No.: HY-15897CAS No.: 1432597-26-6Molecular Formula: CHNMolecular Weight: 406.48Target: TGF- ReceptorPathway: TGF-beta/SmadStorage: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 monthSolvent possesses a bias towards ALK2(IC50=1.3 nM) versus ALK1 and ALK3 compared to othe
2、r inhibitors.IC50 value: 1.3 nM 1Target: ALK2 In vitro, LDN-212854 exhibits some selectivity for ALK2 in preference to other BMP type I receptors, ALK1 and ALK3, which may permit the interrogation of ALK2-mediated signaling, transcriptional activity and function. LDN-212854 potently inhibitsheteroto
3、pic ossification in an inducible transgenic mutant ALK2 mouse model of fibrodysplasia ossificans progressiva.REFERENCES1. Mohedas AH, et al. Development of an ALK2-biased BMP type I receptor kinase inhibitor. ACS Chem Biol. 2013;8(6):1291-302.Product Data Sheet InhibitorsAgonistsScreening Librarieswww.MedChemE1Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: techMedChemEAddress: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USAwww.MedChemE2
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