Bufalin-DataSheet-MedChemExpress.pdf
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1、BufalinCat. No.: HY-N0877CAS No.: 465-21-4Molecular Formula: CHOMolecular Weight: 386.52Target: OthersPathway: OthersStorage: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 monthSolvent has been shown to exert a potential for anticancer activity against various human cancer cell lines i
2、n vitro.IC50 value:Target: Anticaner natural compoundin vitro: bufalin remarkably inhibited growth in human gallbladder cancer cells by decreasing cell proliferation, inducing cell cycle arrest and apoptosis in a dose-dependent manner. Bufalin also disrupted the mitochondrial membrane potential (m)
3、and regulated the expression of cell cycle and apoptosis regulatory molecules. Activation of caspase-9 and the subsequent activation of caspase-3 indicated that bufalin may be inducing mitochondria apoptosis pathways 1. bufalin suppressed the protein levels associated with DNA damage and repair, suc
4、h as a DNA dependent serine/threonine protein kinase (DNA-PK), DNA repair proteins breast cancer 1, early onset (BRCA1), 14-3-3 (an important checkpoint keeper of DDR), mediator of DNA damage checkpoint 1 (MDC1), O6-ethylguanine-DNA methyltransferase (MGMT) and p53 (tumor suppressor protein) 2. TNF-
5、 significantly increased p65 translocation into nucleus (P 0.01) and enhanced NF-B DNA-binding activity, which were dose-dependently inhibited by bufalin. Furthermore, bufalin attenuated the TNF-induced interleukin-1beta (IL-1), IL-6, and IL-8 production in RAFLSs in a concentration-dependent manner
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