STF-62247-DataSheet-MedChemExpress.pdf
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1、STF-62247Cat. No.: HY-100746CAS No.: 315702-99-9Molecular Formula: CHNSMolecular Weight: 267.35Target: AutophagyPathway: AutophagyStorage: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 monthSolvent & SolubilityIn Vitro DMSO : 31 mg/mL (115.95 mM)* “ means soluble, but saturation unknow
2、n.ConcentrationSolvent Mass 1 mg 5 mg 10 mg1 mM 3.7404 mL 18.7021 mL 37.4041 mL5 mM 0.7481 mL 3.7404 mL 7.4808 mLPreparing Stock Solutions10 mM 0.3740 mL 1.8702 mL 3.7404 mLPlease refer to the solubility information to select the appropriate solvent.BIOLOGICAL ACTIVITYDescription STF-62247 is TGN in
3、hibitor with IC50 of 0.625M and 16M in RCC4 and RCC4/VHL cells,respectively.It specifically induces autophagic cell death in cells that have lost VHL, an essential mutation in the development of RCC.IC50: 0.625/16M in RCC4 and RCC4/VHL cells,respectively.1In vitro: STF-62247 induces cytotoxicity in
4、VHL-deficient cells in a HIF-independent manner, STF-62247 increases acidification in VHL-deficient cells ,TGN is a target of STF-62247 and a drug-selective pathway synthetically lethal in VHL-deficient cells.1 Golgi trafficking are required as initial signals in STF-62247-induced autophagy.2STF-622
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- STF 62247 DataSheet MedChemExpress