AC-55541-DataSheet-MedChemExpress.pdf
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1、AC-55541Cat. No.: HY-14350CAS No.: 916170-19-9Molecular Formula: CHBrNOMolecular Weight: 518.36Target: Protease-Activated Receptor (PAR)Pathway: GPCR/G ProteinStorage: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 monthSolvent activated PAR2 signaling in cellular proliferation assays,
2、phosphatidylinositol hydrolysis assays, and Ca(2+) mobilization assays, with potencies ranging from 200 to 1000 nM.IC50 value: 200-1000 nM(EC50) 1Target: PAR2 agonistNeither AC-55541 nor AC-264613 had activity at any of the other PAR receptor subtypes, nor did they have any significant affinity for
3、over 30 other molecular targets involved in nociception. Visualization of EYFP-tagged PAR2 receptors showed that each compound stimulated internalization of PAR2 receptors. AC-55541 was well absorbed when administered intraperitoneally to rats, reaching micromolar peak plasma concentrations. AC-5554
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- AC 55541 DataSheet MedChemExpress