Rhein_478-43-3_DataSheet_18836_MedChemExpress.PDF
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1、 Inhibitors, Agonists, Screening Librarieswww.MedChemEData SheetBIOLOGICAL ACTIVITY: Rhein is a lipophilic anthraquinone extensively found in medicinal herbs, and has many pharmacological effects, includingepatoprotective, nephroprotective, antiinflammatory, antioxidant, anticancer, and antimicrobia
2、l activities.IC50 value:Target:In vitro: Rhein (0.1 and 1 mg/mL) evidently suppressed cell proliferation and mitogenactivated protein (MAP) kinase activation inhuman colon adenocarcinoma cells (Caco2) but significantly lessened H2O2induced DNA damage and the elevated MDA and ROSlevels induced by H2O
3、2/Fe2+ at the concentrations of 0.110 mg/mL 1.In vivo: Oral administration of rhein (150 mg/kg/d) evidently ameliorated renal interstitial fibrotic lesions and attenuated theexpression of SMA and deposition of fibronectin (FN) in mice with renal interstitial fibrosis induced by unilateral ureteralob
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