Borussertib-DataSheet-MedChemExpress.pdf
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1、BorussertibCat. No.: HY-122913CAS No.: 1800070-77-2Molecular Formula: CHNOMolecular Weight: 596.68Target: AktPathway: PI3K/Akt/mTORStorage: Please store the product under the recommended conditions in the COA.BIOLOGICAL ACTIVITYDescription Borussertib is a covalent-allosteric and first-in-class inhi
2、bitor of protein kinase Akt, with an IC50 of 0.8 nM and a Ki of 2.2 nM for Aktwt1.IC & Target Aktwt0.8 nM (IC50)Aktwt2.2 nM (Ki)In Vitro Borussertib exhibits excellent cellular activity in the nanomolar range with superior profile against clinical candidate Akt inhibitors as well as the cytostatic d
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