Y-27632-dihydrochloride-ROCK-Inhibitor-MedChemExpress.pdf
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1、Y-27632 dihydrochlorideCat. No.: HY-10583CAS No.: 129830-38-2分式: CHClNO分量: 320.26作靶点: ROCK作通路: Cell Cycle/DNA Damage; Stem Cell/Wnt; TGF-beta/Smad储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 H2O : 124 mg/mL (387.19 mM)DMSO : 32 mg/mL (99.92 mM)* “ means soluble, bu
2、t saturation unknown.ConcentrationSolvent Mass 1 mg 5 mg 10 mg1 mM 3.1225 mL 15.6123 mL 31.2246 mL5 mM 0.6245 mL 3.1225 mL 6.2449 mL制备储备液10 mM 0.3122 mL 1.5612 mL 3.1225 mL请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液BIOLOGICAL ACTIVITY物活性 Y-27632 dihydrochloride 是 ATP 竞争性的 ROCK-I 和 ROCK-II 抑制剂, Ki 分别为 220 nM 和 300
3、nM,Y-27632 dihydrochloride 通过上-间充质过渡样调节引发诱导多能细胞 ( hIPSCs) 选择性地分化为间胚层谱系 。IC (2) S-Y (injection of saline i.p. and oral administration of Y27632); (3) DMN-S (DMN i.p. and oral administration of saline); (4) DMN-Y (DMN i.p. and oral administration of Y27632). The rats are weighed every week. They are s
4、acrificed at the end of the fourth week and the liver is excised. In addition, a blood sample is taken immediately before the rats are sacrificed.Animal Administration 34www.MedChemE2MCE has not independently confirmed the accuracy of these methods. They are for reference only.客户使本产品发表的科研献See more c
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