1、(憳搀欀鰒憵憳讀缁吀懁頀h椀欂較較較吔愀瘀愀戀漀爀漀氀攀一愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀瀀椀挀最椀昀吀愀瘀愀戀漀爀漀氀攀一愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀尀尀昀挀挀搀搀搀愀愀愀圀洀堀唀唀渀栀圀眀昀漀砀焀挀最倀焀洀琀戀昀刀挀礀甀伀氀琀洀昀最吀愀瘀愀戀漀爀漀氀攀一愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀昀搀挀昀昀攀攀搀愀昀挀戀攀攀昀搀挀漀琀氀椀渀攀渀栀椀戀椀琀漀爀猀最漀渀椀猀琀猀匠挀爀攀攀渀椀渀最椀戀爀愀爀椀攀猀眀眀眀攀搀栀攀洀吀愀瘀愀戀漀爀漀氀攀愀琀一漀夀匀一漀匀礀渀漀渀礀洀猀一蜀蘀伀舀尀摏瘯甀渀最愀氀尀摏渀琀椀椀渀昀攀挀琀椀漀渀塐礀攀愀爀猀倀漀眀搀攀爀礀攀愀爀猀洀漀渀琀
2、栀猀渀猀漀氀瘀攀渀琀洀漀渀琀栀灠湥匀鹙豛匀伀攀洀最洀洀攠洀攀愀渀猀猀漀氀甀戀氀攀戀甀琀猀愀琀甀爀愀琀椀漀渀甀渀欀渀漀眀渀愀猀猀匀漀氀瘀攀渀琀漀渀挀攀渀琀爀愀琀椀漀渀洀最洀最洀最洀洀洀洀洀洀洀洀洀洀洀洀湨葎蒐盿葭塏豟偧湨葠鹶豛楒豲潾厐葟葒葮跿鵑麋豛鱾葧恓叿蕏鹑豛蒚尯摳叿罙摏蓿葮湨塐慛厐塏葒繶偒葎卶恹偓鶋轏匀伀倀吀眀攀攀渀猀愀氀椀渀攀匀漀氀甀戀椀氀椀琀礀攀洀最洀洀氀攀愀爀猀漀氀甀琀椀漀渀鶋轏匀伀匀椀渀猀愀氀椀渀攀匀漀氀甀戀椀氀椀琀礀攀洀最洀洀氀攀愀爀猀漀氀甀琀椀漀渀匀蕏鹑豛愀猀琀攀爀漀昀匀洀愀氀氀漀氀攀挀甀氀攀猀鵠蒏酶眀眀眀攀搀栀攀洀鶋轏匀伀挀漀爀渀漀椀氀匀漀氀甀戀椀氀椀琀礀攀洀最洀洀氀攀愀爀猀漀
3、氀甀琀椀漀渀伀伀吀嘀吀夀挀椯吀愀瘀愀戀漀爀漀氀攀一f靹面兢振広靬匀癸吀愀瘀愀戀漀爀漀氀攀一猀栀漀眀猀愀渀昀漀氀搀椀渀挀爀攀愀猀攀椀渀愀挀琀椀瘀椀琀礀愀最愀椀渀猀琀渀攀漀昀漀爀洀愀渀猀愀渀搀愀渀昀漀氀搀椀渀挀爀攀愀猀攀椀渀愀挀琀椀瘀椀琀礀愀最愀椀渀猀琀昀甀洀椀最愀琀甀猀嬀崀吀愀瘀愀戀漀爀漀氀攀一漀戀瘀椀漀甀猀氀礀椀渀栀椀戀椀琀琀栀攀挀攀氀氀猀攀砀瀀爀攀猀猀椀渀最氀攀甀刀匀戀甀琀栀愀猀渀漀攀昀昀攀挀琀漀渀琀栀攀挀攀氀氀猀攀砀瀀爀攀猀猀椀渀最氀攀甀刀匀愀渀搀氀攀甀刀匀嬀崀刀刀一匀嬀崀愀欀攀爀匀攀琀愀氀椀猀挀漀瘀攀爀礀漀昀愀渀攀眀戀漀爀漀渀挀漀渀琀愀椀渀椀渀最愀渀琀椀昀甀渀最愀氀愀最攀渀琀昀氀甀漀爀漀
4、搀椀栀礀搀爀漀栀礀搀爀漀砀礀戀攀渀稀漀砀愀戀漀爀漀氀攀一昀漀爀琀栀攀瀀漀琀攀渀琀椀愀氀琀爀攀愀琀洀攀渀琀漀昀漀渀礀挀栀漀洀礀挀漀猀椀猀攀搀栀攀洀甀氀嬀崀娀栀漀甀堀攀琀愀氀倀漀猀琀琀爀愀渀猀昀攀爀攀搀椀琀椀渀最戀礀愀攀甀欀愀爀礀漀琀椀挀氀攀甀挀礀氀琀刀一猀礀渀琀栀攀琀愀猀攀爀攀猀椀猀琀愀渀琀琀漀琀栀攀戀爀漀愀搀猀瀀攀挀琀爀甀洀搀爀甀最一椀漀挀栀攀洀匀攀瀀挀攀倀搀昀攀椀最栀琀愀甀琀椀漀渀倀爀漀搀甀挀琀栀愀猀渀漀琀戀攀攀渀昀甀氀氀礀瘀愀氀椀搀愀琀攀搀昀漀爀洀攀搀椀挀愀氀愀瀀瀀氀椀挀愀琀椀漀渀猀漀爀爀攀猀攀愀爀挀栀甀猀攀漀渀氀礀吀攀氀愀砀洀愀椀氀琀攀挀栀攀搀栀攀洀愀猀琀攀爀漀昀匀洀愀氀氀漀氀攀挀甀氀攀
5、猀鵠蒏酶攀搀栀攀洀砀瀀爀攀猀猀最夀爀爀娀儀吀挀戀最嘀夀昀堀猀伀栀吀漀砀最渀爀甀栀眀甀伀稀愀吀儀焀愀儀樀欀匀圀最伀爀瀀倀昀倀樀吀怀蜀舁萁脀茞倀*谀K渀7憳:k阀胔-冑.棙h縀昂蠃蠃蠃各愀爀椀焀甀椀搀愀爀堀刀愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀瀀椀挀最椀昀吀愀爀椀焀甀椀搀愀爀堀刀愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀尀尀戀搀戀昀攀挀搀戀愀搀愀昀戀挀儀夀挀昀爀儀渀最礀挀栀圀戀挀爀甀最娀渀吀爀礀砀刀爀搀夀夀匀瀀堀稀唀眀吀愀爀椀焀甀椀搀愀爀堀刀愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀愀戀愀昀戀攀攀昀愀搀戀戀昀愀愀昀攀攀B栀*攀搀栀攀洀砀瀀爀攀猀猀一挀椀挀礀焀搀爀倀栀爀唀吀礀漀稀爀猀匀一搀刀爀
6、瀀砀欀欀伀洀夀甀漀爀最娀圀爀樀爀吀騀F憲J阀胔-繒棙i縀$敬老院防暑降温工作总结.docxpic1.gif敬老院防暑降温工作总结.docx2019-88b5a1a7ef-3fe8-46f6-84a1-3785278e88daxPTZZQ6X0cc5JGQGaPwPbB+vp8RfQhq1v3ydzZI+p5ANuqiF/oDXEw=敬老院,防暑降温,工作总结b56a8da6f9086bd62b188b3d6d74ee3b敬老院防暑降温工作总结敬老院防暑降温工作总结 近日持续高温，炎热难耐，民政办多管齐下，认真做 好敬老院的防暑降温工作，并组织检查小组每日对各敬老 院防暑降温工作进行抽查，保证五
7、保老人安全度过酷暑。 一是保持院内环境整洁。要求敬老院及时清理院内垃 圾杂草，打扫老人宿舍，消灭蚊蝇老鼠，消除杂物异味， 另外也积极保持老年人居室通风安静、清洁卫生，做好室 内的防暑降温，合理的关闭门窗，经常通风换气，适当延 长老年活动室开放时间，组织开展适合老人的纳凉活动， 并R(懒匀%懙懒讀缁戉頀h怀椀猃猃猃猃猃猃猃猃猃猃猃猃猃猃猃猃葴屝搀漀挀砀瀀椀挀最椀昀葴屝搀漀挀砀尀尀搀攀昀攀挀搀搀愀戀搀挀攀挀戀攀愀氀圀猀洀漀唀匀甀爀一爀搀渀眀樀琀挀戀伀愀爀砀吀挀刀嘀搀洀栀琀伀爀琀屝慾挀愀搀愀挀昀攀挀搀戀攀挀攀b栀!需蝜儀搀琀圀欀最愀伀挀搀爀戀礀最倀稀伀渀愀吀焀瘀倀瘀堀搀戀昀焀戀圀伀戀吀爀戀稀堀漀堀愀
8、眀吀礀堀蜀蔁蜁蘘嘀頀唀旑M騀F懙勄J阀胔-b縀鸀鐂嘃嘃嘃嘃嘃嘃嘃嘃嘃嘃嘃嘃嘃嘃嘃嘃葴屝搀漀挀砀瀀椀挀最椀昀葴屝搀漀挀砀尀尀搀攀昀攀挀搀搀愀戀搀挀攀挀戀攀愀氀圀猀洀漀唀匀甀爀一爀搀渀眀樀琀挀戀伀愀爀砀吀挀刀嘀搀洀栀琀伀爀琀屝慾挀愀搀愀挀昀攀挀搀戀攀挀攀b栀!需蝜儀搀琀圀欀最愀伀挀搀爀戀礀最倀稀伀渀愀吀焀瘀倀瘀堀搀戀昀焀戀圀伀戀吀爀戀稀堀漀堀愀眀吀礀騀F懛橌J胔-b縀鸀鐂搃搃搃搃搃搃搃搃搃搃搃搃搃搃搃搃氃技屝搀漀挀砀瀀椀挀最椀昀氀技屝搀漀挀砀尀尀昀攀愀愀挀搀愀搀攀愀昀愀昀挀琀愀樀昀搀瘀戀伀樀倀洀稀愀瀀漀伀挀娀堀匀最椀倀稀猀伀攀吀甀嘀眀氀技屝昀搀攀攀戀挀攀戀攀戀昀愀挀W栀D蘀需蝜漀琀渀堀攀砀最倀稀圀
9、唀漀攀琀焀琀昀欀猀焀瀀栀爀匀瘀愀唀匀最圀嘀刀一氀焀唀騀F懙勄J阀胔-棙h縀爃爃爃爃爃爃爃爃爃爃爃爃爃爃爃爃葴屝搀漀挀砀瀀椀挀最椀昀葴屝搀漀挀砀尀尀搀攀昀攀挀搀搀愀戀搀挀攀挀戀攀愀氀圀猀洀漀唀匀甀爀一爀搀渀眀樀琀挀戀伀愀爀砀吀挀刀嘀搀洀栀琀伀爀琀屝慾挀愀搀愀挀昀攀挀搀戀攀挀攀b栀!需蝜儀搀琀圀欀最愀伀挀搀爀戀礀最倀稀伀渀愀吀焀瘀倀瘀堀搀戀昀焀戀圀伀戀吀爀戀稀堀漀堀愀眀吀礀堀騀F懛橌J胔-棙h縀倃堃堃堃考考考考考考考考考考考考考考考考氄技屝搀漀挀砀瀀椀挀最椀昀氀技屝搀漀挀砀尀尀昀攀愀愀挀搀愀搀攀愀昀愀昀挀琀愀樀昀搀瘀戀伀樀倀洀稀愀瀀漀伀挀娀堀匀最椀倀稀猀伀攀吀甀嘀眀氀技屝昀搀攀攀戀挀攀戀攀戀昀愀挀
10、W栀D蘀需蝜漀琀渀堀攀砀最倀稀圀唀漀攀琀焀琀昀欀猀焀瀀栀爀匀瘀愀唀匀最圀嘀刀一氀焀唀騀F懛橌J胔-棙i縀$茷敬老院个人工作总结.docxpic1.gif敬老院个人工作总结.docx2019-880fe78a81-25a2-4cda-9de2-4afa97f3323ct03ajGfdEvb6EG7EO4j2PIm5zap5A7oOEcZCLGXSgiPzsOCeT4uLVw=敬老院,个人,工作总结3fd764eeb9c113eb1490136e5b04fac7輀埰林小宇0002000001思想汇报20190808伀(憾搀輀%懛憾讀缁戉頀h怀椀眂錃錙錙猙猚甚吚愀稀愀爀漀琀攀渀攀一愀琀愀匀栀攀攀琀攀
11、搀栀攀洀砀瀀爀攀猀猀瀀搀昀瀀椀挀最椀昀吀愀稀愀爀漀琀攀渀攀一愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀尀尀攀攀愀攀愀挀昀夀娀礀爀焀渀樀琀礀昀唀圀焀樀猀猀礀唀稀娀稀夀猀匀洀一琀戀攀吀愀稀愀爀漀琀攀渀攀一愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀攀挀挀挀攀愀攀昀愀攀昀愀戀攀漀琀氀椀渀攀渀栀椀戀椀琀漀爀猀最漀渀椀猀琀猀匠挀爀攀攀渀椀渀最椀戀爀愀爀椀攀猀眀眀眀攀搀栀攀洀吀愀稀愀爀漀琀攀渀攀愀琀一漀夀匀一漀匀礀渀漀渀礀洀猀一舀脠舀脠丠伀舀匠尀摏瘯刀刀刀堀刀尀摏攀琀愀戀漀氀椀挀渀稀礀洀攀倀爀漀琀攀愀猀攀塐礀攀愀爀猀倀漀眀搀攀爀礀攀愀爀猀洀漀渀琀栀猀渀猀漀氀瘀攀渀琀洀漀渀琀栀灠湥匀鹙豛伀洀最洀椀渀猀漀氀甀戀氀
12、攀湨葎蒐盿葭塏豟偧伀伀吀嘀吀夀挀椯吀愀稀愀爀漀琀攀渀攀一碞卓刀刀擿踯靬酵坥冔豵匀癸吀愀稀愀爀漀琀攀渀攀一椀渀戀漀琀栀最攀氀愀渀搀挀爀攀愀洀昀漀爀洀甀氀愀琀椀漀渀猀栀愀猀戀攀攀渀甀猀攀搀戀漀琀栀愀猀洀漀渀漀琀栀攀爀愀瀀礀愀渀搀愀猀愀渀愀搀樀甀瘀愀渀琀琀栀攀爀愀瀀礀漀爀瀀猀漀爀椀愀猀椀猀椀琀栀愀猀戀攀攀渀挀漀洀戀椀渀攀搀眀椀琀栀猀琀攀爀漀椀搀猀挀愀氀挀椀瀀漀琀爀椀攀渀攀愀渀搀瀀栀漀琀漀琀栀攀爀愀瀀礀愀渀搀昀漀爀愀挀渀攀眀椀琀栀愀渀琀椀戀椀漀琀椀挀猀吀愀稀愀爀漀琀攀渀攀一栀愀猀戀攀攀渀猀栀漀眀渀琀漀甀瀀爀攀最甀氀愀琀攀琀栀攀琀甀洀漀爀猀甀瀀瀀爀攀猀猀漀爀吀愀稀愀爀漀琀攀渀攀一椀渀搀甀挀攀搀最攀渀攀眀
13、栀椀挀栀椀猀漀瘀攀爀攀砀瀀爀攀猀猀攀搀椀渀瀀猀漀爀椀愀猀椀猀愀渀搀猀欀椀渀挀愀渀挀攀爀嬀崀渀栀甀洀愀渀攀瀀椀搀攀爀洀愀氀挀攀氀氀挀甀氀琀甀爀攀猀吀愀稀愀爀漀琀攀渀攀一猀甀瀀瀀爀攀猀猀攀猀琀栀攀最攀渀攀攀砀瀀爀攀猀猀椀漀渀漀昀洀愀爀欀攀爀瀀爀漀琀攀椀渀猀刀倀挀愀氀最爀愀渀甀氀椀渀愀渀搀匀倀猀欀椀渀搀攀爀椀瘀攀搀愀渀琀椀氀攀甀欀漀瀀爀漀琀攀椀渀愀猀攀栀椀最栀氀礀攀氀攀瘀愀琀攀搀椀渀瀀猀漀爀椀愀琀椀挀攀瀀椀搀攀爀洀椀猀嬀崀吀漀瀀椀挀愀氀最攀氀愀瀀瀀氀椀挀愀琀椀漀渀瀀爀漀瘀椀搀攀猀搀椀爀攀挀琀搀攀氀椀瘀攀爀礀漀昀吀愀稀愀爀漀琀攀渀攀一椀渀琀漀琀栀攀猀欀椀渀琀栀漀甀爀猀愀昀琀攀爀愀琀漀瀀椀挀愀氀愀瀀瀀氀
14、椀挀愀琀椀漀渀漀昀吀愀稀愀爀漀琀攀渀攀一最攀氀琀漀琀栀攀猀欀椀渀漀昀栀攀愀氀琀栀礀椀渀搀椀瘀椀搀甀愀氀猀愀渀搀瀀愀琀椀攀渀琀猀眀椀琀栀瀀猀漀爀椀愀猀椀猀愀瀀瀀爀漀砀椀洀愀琀攀氀礀琀漀漀昀琀栀攀搀漀猀攀爀攀猀椀搀攀猀椀渀琀栀攀猀琀爀愀琀甀洀挀漀爀渀攀甀洀愀渀搀漀昀琀栀攀搀漀猀攀搀椀猀琀爀椀戀甀琀攀搀琀漀琀栀攀瘀椀愀戀氀攀攀瀀椀搀攀爀洀椀猀愀渀搀搀攀爀洀椀猀吀愀稀愀爀漀琀攀渀攀一椀猀搀攀猀椀最渀攀搀琀漀甀渀搀攀爀最漀爀愀瀀椀搀愀渀搀挀漀洀瀀氀攀琀攀匀蕏癸愀猀琀攀爀漀昀匀洀愀氀氀漀氀攀挀甀氀攀猀鵠蒏酶眀眀眀攀搀栀攀洀洀攀琀愀戀漀氀椀猀洀琀漀椀琀猀愀挀琀椀瘀攀洀攀琀愀戀漀氀椀琀攀琀愀稀愀爀漀琀攀渀椀挀
15、愀挀椀搀吀愀稀愀爀漀琀攀渀椀挀愀挀椀搀栀愀猀愀猀栀漀爀琀猀礀猀琀攀洀椀挀爀攀猀椀搀攀渀挀攀琀椀洀攀愀渀搀氀椀洀椀琀攀搀琀椀猀猀甀攀搀椀猀琀爀椀戀甀琀椀漀渀椀渀愀渀椀洀愀氀猀嬀崀圀栀攀渀琀漀瀀椀挀愀氀氀礀愀瀀瀀氀椀攀搀吀愀稀愀爀漀琀攀渀攀一戀氀漀挀欀猀琀栀攀椀渀搀甀挀琀椀漀渀漀昀漀爀渀椀琀栀椀渀攀搀攀挀愀爀戀漀砀礀氀愀猀攀伀愀挀琀椀瘀椀琀礀戀礀琀栀攀琀甀洀漀甀爀瀀爀漀洀漀琀攀爀伀琀攀琀爀愀搀攀挀愀渀漀礀氀瀀栀漀爀戀漀氀愀挀攀琀愀琀攀吀倀椀渀琀栀攀攀瀀椀搀攀爀洀椀猀漀昀琀栀攀栀愀椀爀氀攀猀猀洀漀甀猀攀嬀崀刀刀一匀嬀崀吀愀氀瀀甀爀刀攀琀愀氀昀昀椀挀愀挀礀愀渀搀猀愀昀攀琀礀漀昀琀漀瀀椀挀愀氀琀愀稀愀爀
16、漀琀攀渀攀愀爀攀瘀椀攀眀砀瀀攀爀琀伀瀀椀渀爀甀最攀琀愀戀吀漀砀椀挀漀氀攀戀嬀崀一愀最瀀愀氀匀攀琀愀氀一攀最愀琀椀瘀攀爀攀最甀氀愀琀椀漀渀漀昀琀眀漀栀礀瀀攀爀瀀爀漀氀椀昀攀爀愀琀椀瘀攀欀攀爀愀琀椀渀漀挀礀琀攀搀椀昀昀攀爀攀渀琀椀愀琀椀漀渀洀愀爀欀攀爀猀戀礀愀爀攀琀椀渀漀椀挀愀挀椀搀爀攀挀攀瀀琀漀爀猀瀀攀挀椀昀椀挀爀攀琀椀渀漀椀搀椀渀猀椀最栀琀椀渀琀漀琀栀攀洀攀挀栀愀渀椀猀洀漀昀爀攀琀椀渀漀椀搀愀挀琀椀漀渀椀渀瀀猀漀爀椀愀猀椀猀攀氀氀爀漀眀琀栀椀昀昀攀爀攀挀嬀崀吀愀渀最椀甀攀琀愀氀氀椀渀椀挀愀氀瀀栀愀爀洀愀挀漀欀椀渀攀琀椀挀猀愀渀搀搀爀甀最洀攀琀愀戀漀氀椀猀洀漀昀琀愀稀愀爀漀琀攀渀攀愀渀漀瘀攀氀琀
17、漀瀀椀挀愀氀琀爀攀愀琀洀攀渀琀昀漀爀愀挀渀攀愀渀搀瀀猀漀爀椀愀猀椀猀氀椀渀倀栀愀爀洀愀挀漀欀椀渀攀琀伀挀琀挀攀倀搀昀攀椀最栀琀愀甀琀椀漀渀倀爀漀搀甀挀琀栀愀猀渀漀琀戀攀攀渀昀甀氀氀礀瘀愀氀椀搀愀琀攀搀昀漀爀洀攀搀椀挀愀氀愀瀀瀀氀椀挀愀琀椀漀渀猀漀爀爀攀猀攀愀爀挀栀甀猀攀漀渀氀礀吀攀氀愀砀洀愀椀氀琀攀挀栀攀搀栀攀洀愀猀琀攀爀漀昀匀洀愀氀氀漀氀攀挀甀氀攀猀鵠蒏酶攀搀栀攀洀砀瀀爀攀猀猀圀匀堀瘀戀昀挀一琀猀堀欀琀洀搀唀刀搀甀栀瘀猀欀眀吀渀挀娀夀娀唀愀最嘀欀甀伀昀攀唀漀爀吀Hotline: 400-820-3792 InhibitorsAgonistsScreening Libraries www.Me
18、dChemE Tenofovir Disoproxil Fumarate Cat. No.:HY-13782 CAS No.:202138-50-9 Synonyms:Tenofovir DF 分式:CHNOP 分量:635.51 作靶点:HIV; Reverse Transcriptase; HBV 作通路:Anti-infection 储存式:-20C3 yearsPowder 4C2 years -80C6 monthsIn solvent -20C1 month 溶解性数据 体外实验DMSO : 50 mg/mL (78.68 mM) H2O : 16.67 mg/mL (26.23
19、mM; Need ultrasonic and warming) * “ means soluble, but saturation unknown. Mass Solvent Concentration 1 mg5 mg10 mg 1 mM1.5735 mL7.8677 mL15.7354 mL 5 mM0.3147 mL1.5735 mL3.1471 mL 10 mM0.1574 mL0.7868 mL1.5735 mL 制备储备液 请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备
20、液，再依次添加助溶剂 (为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条 件，适当保存；以下溶剂前的百分是指该溶剂在您配制终溶液中的体积占)： 1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline Solubility: 2.5 mg/mL (3.93 mM); Clear solution 2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline) 体内实验 1/3Master of Small Molecules 您边的抑制剂师 www.MedChem
21、E Solubility: 2.5 mg/mL (3.93 mM); Clear solution 3. 请依序添加每种溶剂： 10% DMSO 90% corn oil Solubility: 2.5 mg/mL (3.93 mM); Clear solution BIOLOGICAL ACTIVITY 物活性 Tenofovir Disoproxil Fumarate是于治疗 HIV 和慢性型肝炎的核苷酸逆转录酶抑制剂。 体外研究 Tenofovir shows cytotoxic effects on cell viability in HK-2 cells, with IC50 val
22、ues of 9.21 and 2.77 M at 48 and 72 h in MTT assay, respectively. Tenofovir diminishes ATP levels in HK-2 cells. Tenofovir (3.0 to 28.8 M) increases oxidative stress and protein carbonylation in HK-2 cells. Furthermore, Tenofovir induces apoptosis in HK-2 cells, and that apoptosis is induced via mit
23、ochondrial damage 1. Tenofovir and M48U1 formulated in 0.25% HEC each inhibits the replication of both R5-tropic HIV-1BaL and X4-tropic HIV-1IIIb in activated PBMCs, and inhibits several laboratory strains and patient-derived HIV-1 isolates. The combined formulation of M48U1 and tenofovir in 0.25% H
24、EC exhibits synergistic antiretroviral activity against infection with R5-tropic HIV-1BaL, and is not toxic to PBMCs 2. 体内研究Tenofovir Disoproxil Fumarate (20, 50, 140, or 300 mg/kg) administered to BLT mice, shows dose dependent activity during vaginal HIV challenge in BLT humanized mice. Tenofovir
25、Disoproxil Fumarate (50, 140, 300 mg/kg) significantly reduces HIV transmission in BLT mice 3. Tenofovir Disoproxil Fumarate (0.5, 1.5, or 5.0 mg/kg/day, p.o.) induces a dose-dependent decline in serum viremia in woodchucks chronically infected with WHV. Tenofovir Disoproxil Fumarate administration
26、is safe and effective in the woodchuck model of chronic HBV infection 4. PROTOCOL Cell Assay 1Cells are plated into 48-well tissue culture plates (39,000 cells/mL) and allowed to grow for 48 h followed by treatment with vehicle or Tenofovir. Following the treatment period, cell viability is assessed using the MTT assay. The MTT assay relies on the conversion of tetrazolium dye 3-(4,5-di
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