Lomitapide-DataSheet-MedChemExpress.pdf
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Lomitapide-DataSheet-MedChemExpress.pdf
1、LomitapideCat. No.: HY-14667CAS No.: 182431-12-5Molecular Formula: CHFNOMolecular Weight: 693.72Target: OthersPathway: OthersStorage: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 monthSolvent BMS-201038) is a potent inhibitor of microsomal triglyceride-transfer protein (MTP) with an I
2、C50 of 8 nM in vitro.IC 14(20):5067-70.2. Davis KA. et al. Lomitapide: A novel agent for the treatment of homozygous familial hypercholesterolemia. Am J Health Syst Pharm. 2014 Jun 15;71(12):1001-8.3. Dhote V, et al. Inhibition of microsomal triglyceride transfer protein improves insulin sensitivity
3、 and reduces atherogenic risk in Zucker fatty rats. Clin Exp Pharmacol Physiol. 2011 May;38(5):338-44.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: techMedChemEAddress: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USAwww.MedChemE2