1、Micafungin sodiumCat. No.: HY-16321CAS No.: 208538-73-2Molecular Formula: CHNNaOSMolecular Weight: 1292.26Target: FungalPathway: Anti-infectionStorage: 4C, protect from lightSolvent micafungin at 0.1, 0.32 or 1 mg/kg of body weight/dose given subcutaneously (s.c.) (q.d.); micafungin given s.c. (0.1,
2、 0.32 or 1 mg/kgq.d.) plus KB425796-C given i.p. (32 mg/kg) twice daily (b.i.d.); and saline (b.i.d.). Drugs are administered on days 1 and 2. Five mice in each group are killed 1 day after the completion of treatment. The livers and kidneys are aseptically removed, and each organ is then homogenize
3、d in 5 mL sterile saline. Serial 10-fold dilutions of the homogenates are plated on PDA and incubated for 48 h at 37C, and the numbers of CFU per gram of tissue are then calculated. The survival rate of remaining five mice of each group are examined daily for 31 days after the challenge.MCE has not
4、independently confirmed the accuracy of these methods. They are for reference only.CUSTOMER VALIDATIONSee more customer validations on www.MedChemEREFERENCES1. Bazzi W, et al. The inhibitory effect of micafungin on biofilm formation by Pseudomonas aeruginosa. Biofouling. 2013 Jul 23.2. Kai H, et al.
5、 Synergistic antifungal activity of KB425796-C in combination with micafungin against Aspergillus fumigat us and its efficacy in murine infection models. J Antibiot (Tokyo). 2013 Jun 12.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: techMedChemEAddress: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA Sci Rep. 2017 Feb 17;7:42886. J Clin Microbiol. 2017 Jun;55(6):1883-1893.www.MedChemE2
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