1、帀(币搀椀币币币讀缁缀済漁螏頀h砀椀嬂眃眃眃愈椈椈椈鄈鄈鄈鄈鄈鄈鄈鄈鄈鄈鄈鄈鄈鄈鄈鄈鄈鄈錈爀椀琀愀渀渀椀氀愀挀琀漀渀攀愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀瀀椀挀最椀昀爀椀琀愀渀渀椀氀愀挀琀漀渀攀愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀尀尀攀攀攀攀戀搀搀搀戀搀攀挀攀戀娀礀戀搀洀伀攀氀愀眀瀀栀洀琀礀瀀礀甀爀洀渀儀砀砀戀氀攀渀欀刀愀爀漀爀瘀吀刀挀娀爀椀琀愀渀渀椀氀愀挀琀漀渀攀愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀愀愀搀戀搀愀戀戀挀搀爀椀琀愀渀渀椀氀愀挀琀漀渀攀愀琀一漀夀一匀一漀漀氀攀挀甀氀愀爀漀爀洀甀氀愀脀蔠舀舠传萀漀氀攀挀甀氀愀爀圀攀椀最栀琀吀愀爀最攀琀伀琀栀攀爀猀倀愀琀栀眀愀礀伀琀栀
2、攀爀猀匀琀漀爀愀最攀倀氀攀愀猀攀猀琀漀爀攀琀栀攀瀀爀漀搀甀挀琀甀渀搀攀爀琀栀攀爀攀挀漀洀洀攀渀搀攀搀挀漀渀搀椀琀椀漀渀猀椀渀琀栀攀伀匀漀氀瘀攀渀琀愀甀琀椀漀渀倀爀漀搀甀挀琀栀愀猀渀漀琀戀攀攀渀昀甀氀氀礀瘀愀氀椀搀愀琀攀搀昀漀爀洀攀搀椀挀愀氀愀瀀瀀氀椀挀愀琀椀漀渀猀漀爀爀攀猀攀愀爀挀栀甀猀攀漀渀氀礀吀攀氀愀砀洀愀椀氀琀攀挀栀攀搀栀攀洀砀瀀爀攀猀猀挀漀洀搀搀爀攀猀猀攀攀爀倀愀爀欀爀匀甀椀琀攀儀漀渀洀漀甀琀栀甀渀挀琀椀漀渀一唀匀倀爀漀搀甀挀琀愀琀愀匀栀攀攀琀渀栀椀戀椀琀漀爀猀最漀渀椀猀琀猀匠挀爀攀攀渀椀渀最椀戀爀愀爀椀攀猀眀眀眀攀搀栀攀洀砀瀀爀攀猀猀挀漀洀攀搀栀攀洀砀瀀爀攀猀猀渀7币礎:e胔-輀%棙
3、i缀笝$BRL44385-DataSheet-MedChemExpress.pdfpic1.gifBRL44385DataSheetMedChemExpress.pdf2019-531946bd55a-fd25-42c4-ab37-864a50518f16vW9gi9OIwkL92ZYE5wVgl0LzhKtoXiZDKyiY0Qd314I2pguhayYB6A=BRL44385,DataSheet,MedChemExpress83fe3f24b2babd562a14fbe0b0e37185BRL44385Cat. No.: HY-U00224CAS No.: 114778-60-8Molec
4、ular Formula: CHNOMolecular Weight: 225.2Target: HSVPathway: Anti-infectionStorage: Please store the product under the recommended conditions in the COA.Solvent HSV-2In Vivo BRL44385 is a selective antiherpesvirus agent. Following oral administration, BRL 55792 is very well absorbed and provides hig
5、h and prolonged concentrations of BRL44385 in the blood. In mice 15 min and 60 min after administration of a single oral dose of BRL 55792, the concentrations of BRL44385 in the blood are considerably higher than those obtain after oral administration of either BRL44385 or BRL46720 and the bioavaila
6、bility of BRL 44385 from oral BRL 55792 is 66% of that achieves with the same dose of the sodium salt of BRL44385 administered intravenously1.PROTOCOLProduct Data Sheet InhibitorsAgonistsScreening Librarieswww.MedChemE1Animal Administration 1Mice1 BRL44385 is administered as a single dose of 0.2 mmo
7、l/kg in 0.1 mL of 1% carboxymethylcellulose by oral gavage to female Balb/c mice weighing approximately 20 g. Food is withheld for 18 h prior to the start of the experiment. Blood is collected by cardiac puncture using heparinized syringes 15, 60, and 180 min after dosing. Equal volumes (0.2 mL) fro
8、m three mice are pooled at each time point and 0.6 mL of 16% trichloroacetic acid is added. After centrifugation, 0.5 mL of supernatant is added to 0.1 mL of saturated aqueous NaHCO3 followed by the addition of 0.6 mL of 0.4 mM NH4OAc (pH 6.0) and the mixture analysed by HPLC. MCE has not independen
9、tly confirmed the accuracy of these methods. They are for reference only.REFERENCES1. M. R. Harnden, et al. Synthesis, oral bioavailability and in vivo activity of acetal derivatives of the selective antiherpesvirus agent 9-(3-hydroxypropoxy) guanine (SRL 44385). Antiviral Chemistry & Chemotherapy (
10、1994) 5(3), 147-154.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: techMedChemEAddress: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USAwww.MedChemE2MedChemExpress0001200001可研报告20190531134349545965B砀(
11、币匀攀币氂币币讀缁缀渌漁螏頀h砀椀蜂匂圄弄弄弄蜄蜄蜄蜄蜄蜄蜄蜄蜄蜄蜄蜄蜄蜄蜄蜄蜄蜄褄礀搀爀漀砀礀瀀爀漀瀀礀氀戀攀琀愀挀礀挀氀漀搀攀砀琀爀椀渀匀匀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀瀀椀挀最椀昀礀搀爀漀砀礀瀀爀漀瀀礀氀戀攀琀愀挀礀挀氀漀搀攀砀琀爀椀渀匀匀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀尀尀愀搀愀攀戀昀挀戀戀戀攀愀昀愀挀挀倀戀堀伀琀圀栀唀礀漀甀堀砀猀椀爀戀氀漀栀倀砀渀戀娀夀伀挀猀樀儀戀眀礀搀爀漀砀礀瀀爀漀瀀礀氀戀攀琀愀挀礀挀氀漀搀攀砀琀爀椀渀匀匀攀搀栀攀洀砀瀀爀攀猀猀昀戀昀挀戀攀戀攀昀挀攀栀堀L攀搀栀攀洀砀瀀爀攀猀猀靓言茀渀7币沃:e區胔-輀8棙i缀$3-Methylthio-propionic-acid-D
12、ataSheet-MedChemExpress.pdfpic1.gif3MethylthiopropionicacidDataSheetMedChemExpress.pdf2019-5312645dace-8962-41af-9cce-b3c026111f0bKlL0ABKV7xLQvwdqaumrMQj1j0zCJ6gv3JN1OltKeMiv6QKAqqObSw=Methylthio,propionic,acid,DataSheet,MedChemExpress9d66e7b8f471fff3d8e2e78bfaf5289b3-(Methylthio)propionic acidCat.
13、No.: HY-101401CAS No.: 646-01-5Molecular Formula: CHOSMolecular Weight: 120.17Target: FungalPathway: Anti-infectionStorage: Pure form -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 monthSolvent 253(21):7844-50.2. Surette R, et al. Formation of 3-methylthioacrylic acid from methionine by Strept
14、omyces lincolnensis. Isolation of a peroxidase. J Antibiot (Tokyo). 1976 Jun;29(6):646-52.3. Kim YC, et al. 3-methylthiopropanoic acid produced by Enterobacter intermedium 60-2G inhibits fungal growth and weed seedling development. J Antibiot (Tokyo). 2003 Feb;56(2):177-80.4. Nakamura Y, et al. 3-Me
15、thylthiopropionic acid ethyl ester, isolated from Katsura-uri (Japanese pickling melon, Cucumis melo var. conomon), enhanced differentiation in human colon cancer cells. J Agric Food Chem. 2008 May 14;56(9):2977-84.Caution: Product has not been fully validated for medical applications. For research
16、use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: techMedChemEAddress: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USAwww.MedChemE2MedChemExpress0001500006先进医疗20190531140857134933?0谌(瀀币搀需翹匀頀币币瀀币讀缁渒漁螏頀h砀椀鄂缃愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀瀀椀挀最椀昀愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀尀尀攀愀搀愀愀昀挀愀搀挀礀圀娀夀匀栀漀刀瘀洀昀夀甀氀爀椀眀昀挀刀
17、爀焀堀栀氀儀渀椀娀儀愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀搀搀昀愀挀搀攀愀戀昀愀搀昀愀琀一漀夀匀一漀漀氀攀挀甀氀愀爀漀爀洀甀氀愀茀茠茀脠氀舀丠茀传蔀漀氀攀挀甀氀愀爀圀攀椀最栀琀吀愀爀最攀琀瀀椀最攀渀攀琀椀挀刀攀愀搀攀爀漀洀愀椀渀倀愀琀栀眀愀礀瀀椀最攀渀攀琀椀挀猀匀琀漀爀愀最攀倀漀眀搀攀爀礀攀愀爀猀礀攀愀爀猀渀猀漀氀瘀攀渀琀洀漀渀琀栀猀洀漀渀琀栀匀漀氀瘀攀渀琀愀甀琀椀漀渀倀爀漀搀甀挀琀栀愀猀渀漀琀戀攀攀渀昀甀氀氀礀瘀愀氀椀搀愀琀攀搀昀漀爀洀攀搀椀挀愀氀愀瀀瀀氀椀挀愀琀椀漀渀猀漀爀爀攀猀攀愀爀挀栀甀猀攀漀渀氀礀吀攀氀愀砀洀愀椀氀琀攀挀栀攀搀栀攀洀砀瀀爀攀猀猀挀漀洀搀搀爀攀猀猀攀攀爀倀愀爀欀爀匀甀椀
18、琀攀儀漀渀洀漀甀琀栀甀渀挀琀椀漀渀一唀匀眀眀眀攀搀栀攀洀砀瀀爀攀猀猀挀漀洀攀搀栀攀洀砀瀀爀攀猀猀靓茀渀7氀币:柌e僨柌胔-輀9棙i缀$萧-2-Hydroxypropyl-beta-cyclodextrin-SDS-MedChemExpress.pdfpic1.gif2HydroxypropylbetacyclodextrinSDSMedChemExpress.pdf2019-53182701ada-ebf7-4cb1-83bb-eaf059ac23c8FPbXOGtWhUCBC+yIMouHX3xsirIAbloJ6Gh7PxGnbZ9Y8Oc+sjQ8bw=Hydroxypropyl,bet
19、a,cyclodextrin,SDS,MedChemExpress1092f3508b5f9c2b3e257b1e28fce734攀MedChemExpress0001500006先进医疗20190531140856009121?(币匀攀币币币讀缁缀尀渖漁螏頀h堀椀錂范國國國國國國國國國國國國國國國國國國夋一刀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀瀀椀挀最椀昀一刀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀尀尀搀戀搀昀昀攀搀昀攀搀搀栀挀倀戀刀栀倀刀氀攀砀夀甀攀琀倀栀搀攀洀挀琀眀搀搀儀堀挀礀洀稀眀一刀攀搀栀攀洀砀瀀爀攀猀猀戀搀戀戀愀挀挀戀挀攀攀瀀瀀洀琀愀琀攀愀礀漀挀甀洀攀渀琀猀吀椀琀氀攀愀琀愀氀漀最一漀夀愀琀挀栀匀瀀攀挀
20、琀爀甀洀吀椀琀氀攀夀开娀圀夀儀爀攀焀甀攀渀挀礀稀昀伀爀椀最椀渀愀氀倀漀椀渀琀猀漀甀渀琀昀挀琀甀愀氀倀漀椀渀琀猀漀甀渀琀昀挀焀甀椀猀椀琀椀漀渀吀椀洀攀猀攀挀昀匀瀀攀挀琀爀愀氀圀椀搀琀栀瀀瀀洀昀倀甀氀猀攀倀爀漀最爀愀洀唀渀欀渀漀眀渀匀愀洀瀀氀攀娀圀夀儀愀琀愀氀漀最一漀夀愀琀挀栀匀伀一伀伀伀氀一伀伀一氀栀攀洀椀挀愀氀漀爀洀甀氀愀氀一伀砀愀挀琀愀猀猀攀搀栀攀洀砀瀀爀攀猀猀靓言茀渀7琀币:悳倀孴胔-怩輀$棙i缀$莧666-15-LCMS-24622-MedChemExpress.pdfpic1.gif66615LCMS24622MedChemExpress.pdf2019-5317fffc4b1-363
21、e-4ca8-acf2-c211f9180801PaDPcw9Q0Wvf6ntt3xH8kcmmsBKafXgBt3rMXngWnwOHfBjf+Y68nA=666,15,LCMS,24622,MedChemExpressda6ab00643c4087e9a6d3967de7bf1eb搀孞MedChemExpress0001500006先进医疗20190531140858899191?.743 8.467 8.445 8.071 8.059 8.051 7.941 7.920 7.835 7.814 7.740 7.728 7.722 7.625 7.623 7.606 7.588 7.585
22、 7.548 7.545 7.527 7.510 7.507 7.483 7.481 7.463 7.445 7.443 7.430 7.400 7.398 7.380 7.362 7.360 7.018 7.012 6.924 6.918 6.902 6.896 4.554 4.539 4.524 4.258 4.244 4.230 3.973 3.959 3.335 2.974 2.509 2.504 2.500 2.496 2.491 2.062 -0.0031.0000.781 2.009 1.010 2.123 4.378 2.154 1.110 1.081 2.050 1.067
23、1.011 1.007 2.035 2.066 2.076 2.216 2.077Date:18 May 2017Documents Title:Catalog No: HY-101120 Batch#24622Spectrum Title:HY_BIZ2017-518-WYQ4Frequency (MHz):(f1) 399.738 Original Points Count:(f1) 65536 Actual Points Count:(f1) 65536 Acquisition Time (sec):(f1) 8.1789 Spectral Width (ppm):(f1) 20.045
24、 Pulse Program:UnknownSample ID: BIZ2017-518-WYQ4, Catalog No: HY-101120 Batch#24622 , DMSONHOOHO ClHNOONH2HClChemicalFormula:C33H31Cl2N3O5Exact Mass: 619.16MedChemExpress0001500006-20190531140858774363?0谎耀(蠀币搀需翹偠琀币琖币蠀币讀缁偠渘漁螏頀h砀椀錂范匀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀瀀椀挀最椀昀匀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀尀尀昀昀昀挀戀攀挀愀愀挀昀挀昀倀愀倀挀眀儀圀瘀昀渀琀琀砀欀挀洀洀猀
25、愀昀堀最琀爀堀渀最圀渀眀伀昀樀昀夀渀匀攀搀栀攀洀砀瀀爀攀猀猀搀愀愀戀挀攀愀搀搀攀戀昀攀戀帀栀)攀搀栀攀洀砀瀀爀攀猀猀挏茀开鬀猀;言茀渀7币惛:b胔-輀/棙i缀欝$DREADD-agonist-21-LCMS-22851-MedChemExpress.pdfpic1.gifDREADDagonist21LCMS22851MedChemExpress.pdf2019-531a5e5cc0e-b522-4cb0-9324-c2517075cd06v52Na5BbStUc+t5Mf+7hhRyOrlpKcz/U1w13xcZlRbPiOC0RCW6v+w=DREADD,agonist,21,LCMS,
26、22851,M爀(币匀搀币币币讀缁缀渜漁螏頀h堀椀塙楢搀漀挀砀瀀椀挀最椀昀塙楢搀漀挀砀尀尀攀愀愀戀戀搀攀挀匀爀匀甀吀娀嘀儀椀猀樀砀瀀愀嘀挀猀瘀堀瘀砀欀砀夀挀堀漀堀焀搀漀琀瘀甀堀堀攀最塙椀昀攀愀攀攀搀攀戀昀昀愀攀搀挀昀氀伀伀塙楢鎑斏汑捹蜀塙忿开开开开开开开开开开开开开开开塙忿开开开开开开开开开开开开开开开忿开开开开开开开开开开开忿开开开开开开开马桎忿开开开开开开开开开开开开开开开忿开开开开开开开夀塙忿开开开开开开开开开开开椀汴忿开开开开开开开开开开开开开开开忿开开开开开开开开开开开忿开开开开开开开马桎忿开开开开开开开开开开开开开开开忿开开开开开开开彟开开开开开开开开开开开萀楶鱏豜汔葥捶罞蹏琰褰桛
27、蜰葦作荳湨彣开开开楞扥蒗貉噥絓余艢低慎楧蕴蹏彎开开开当开开开蒍彶开开开蕖葑楶塙奾鹥谀譴祎葜罶笰椀葖汶蠀澍瀰暈靖鼰怰锰匰尰晐萀罶豏歭荔汎葔屝氀煑轹蜀兒楓蕖昀蚏皈屓椀捎蠀極汴葴癶譎祎豻慎塙楢扴罟轶慎楧偧塙偧彎开开开琀征开开开琀彞开开开彧开开开睥归开开开琀彞开开开彧开开开扥慖湨骉作蕏塙奢鹥楥捶奷汛蒑罴盿汣鹴奾鱥骉葛譫魣抋葹开开开开猀獥奾徑开开开盿麍罴奾魣形开开开猀獥瘀鹎汒形开开开猀獥壿徂开开开猀獥徑开开开奔魣佧蕏馍e坎癙套补靎牟襞奭鵥鵢骉蕛蒈豴奛葥鹴捶瑓骋苿奖豥鑻慎骉葛豨葎乾彭找溍驸佧蕏塙奢楓貉汎葾衢婎屎呎羍乾彭屎尰獧捥屺伀奒婥結奏蜰俿妌蒕獶噥骉罥葢癶谀夀湨獧譬鹔佧蕏楓葴祔甀袐祔貉骉葛腶湨补佧蕏楓鹎
28、滿鹏乾盿罞鑶捶湨佣蕏蕓葏v膗汎虎b蒗葶捶癷屝豥佔蕏桢桔卑鱟汩佛蕏葓汶靎悁豵癓网齵姿艥佗蕏蕓楥豞葛垑祙篿豥獧禕鹓夀筥牼葞齶佧蕏溋葧豧塎佧蕏楓捴癨綋獧靭佻蕏癑魣靭鵎湏杣蒏靎鵧杏塙豢汎葾骉汎豾楔葞桎獧栰榐捴獧馍啟卜葥蝓豒屝墐沄罓佢蕏楓葴祎癒靎作蕏楓葴瑶卥汶百啢鑻慎楧豨乾祔杨榈骉葛祔臿佬蕏套彔开开开琀蕞归开开开谀渀瑏豞祔彨开开开彑开开开姿蒍彶开开开尀敥浻慑榘夀織睥蕥e彞开开开峿榘谀夀豥骉葛豨乾蕥Q梏塧潒眰漀圀N4推胔-輀 棙h缀訂氃唄螋蹗村葵村葾鹎搀漀挀瀀椀挀最椀昀唀螋蹗村葵村葾鹎搀漀挀尀尀愀攀挀搀戀挀搀愀挀昀挀堀最吀戀挀愀焀堀渀稀瀀漀瘀搀刀嘀昀眀琀堀刀眀儀樀搀昀挀氀洀琀戀焀稀攀礀瘀猀栀夀倀最唀螋蹗村鸀扳昀昀愀愀戀挀戀搀挀昀戀昀栀u眀漀螋匀鈀鄀2币N
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