Begacestat-DataSheet-MedChemExpress.pdf
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Begacestat-DataSheet-MedChemExpress.pdf
1、BegacestatCat. No.: HY-14175CAS No.: 769169-27-9Molecular Formula: CHClFNOSMolecular Weight: 391.74Target: -secretasePathway: Neuronal Signaling; Stem Cell/WntStorage: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 monthBIOLOGICAL ACTIVITYDescription Begacestat (GSI-953) is a selective
2、thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase (IC50A40=15 nM) for the treatment of Alzheimers disease1.IC 51(23):7348-51.2. Martone RL, et al. Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the
3、treatment of Alzheimers disease. J Pharmacol Exp Ther. 2009 Nov;331(2):598-608.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: techMedChemEAddress: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USAwww.MedChemE2