1、颜(省搀%棁省鰂冘省省讀缁缀萀耀螏頀h椀礂鼃鼃鼃弌猌笌笌笌栀礀搀爀漀挀栀氀漀爀椀搀攀渀栀椀戀椀琀漀爀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀瀀椀挀最椀昀栀礀搀爀漀挀栀氀漀爀椀搀攀渀栀椀戀椀琀漀爀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀尀尀搀戀挀攀戀攀攀昀愀戀漀稀圀焀戀漀漀儀戀欀儀猀樀漀砀唀樀瘀栀娀儀挀堀攀攀搀瘀攀最嘀栀砀最栀礀搀爀漀挀栀氀漀爀椀搀攀渀栀椀戀椀琀漀爀攀搀栀攀洀砀瀀爀攀猀猀昀愀昀戀愀搀昀挀戀攀昀愀栀礀搀爀漀挀栀氀漀爀椀搀攀愀琀一漀夀匀一漀舀蠠茀耠氀一蔀传匀尀摏瘯刀刀尀摏一甀琀漀瀀栀愀最礀塐倀氀攀愀猀攀猀琀漀爀攀琀栀攀瀀爀漀搀甀挀琀甀渀搀攀爀琀栀攀爀攀挀漀洀洀攀渀搀攀搀挀漀渀搀椀琀椀漀渀猀椀渀琀栀攀伀伀伀吀
2、嘀吀夀挀椯栀礀搀爀漀挀栀氀漀爀椀搀攀f葠癯鄀峿摏踯挀漀洀瀀氀攀砀谀渀渀谀渀嬀崀醏硬癯刀刀渀嬀崀蔀耠嬀崀攀爀洀愀渀猀漀渀匀攀琀愀氀匀挀爀攀攀渀椀渀最昀漀爀渀漀瘀攀氀刀刀椀渀栀椀戀椀琀漀爀猀甀猀椀渀最愀栀椀最栀琀栀爀漀甀最栀瀀甀琀吀刀刀吀挀攀氀氀甀氀愀爀愀猀猀愀礀昀漀爀刀刀匀攀爀瀀栀漀猀瀀栀漀爀礀氀愀琀椀漀渀倀漀匀伀渀攀攀挀攀倀搀昀攀椀最栀琀愀甀琀椀漀渀倀爀漀搀甀挀琀栀愀猀渀漀琀戀攀攀渀昀甀氀氀礀瘀愀氀椀搀愀琀攀搀昀漀爀洀攀搀椀挀愀氀愀瀀瀀氀椀挀愀琀椀漀渀猀漀爀爀攀猀攀愀爀挀栀甀猀攀漀渀氀礀吀攀氀愀砀洀愀椀氀琀攀挀栀攀搀栀攀洀砀瀀爀攀猀猀挀渀愀猀琀攀爀漀昀匀洀愀氀氀漀氀攀挀甀氀攀猀鵠蒏酶偞爀漀搀甀
3、挀琀愀琀愀匀栀攀攀琀渀栀椀戀椀琀漀爀猀最漀渀椀猀琀猀匠挀爀攀攀渀椀渀最椀戀爀愀爀椀攀猀攀氀氀攀愀琀栀椀猀瀀爀洀洀甀渀漀氀瀀爀刀攀猀瀀椀爀刀攀猀匀攀瀀漀氀洀洀甀渀漀氀一漀瘀眀眀眀攀搀栀攀洀砀瀀爀攀猀猀挀渀攀搀栀攀洀砀瀀爀攀猀猀靓攁言茀渀7写省挶:鄀駈胔-)輀A棙i缀$INCB-057643-Epigenetic-Reader-Domain-Inhibitor-MedChemExpress.pdfpic1.gifINCB057643EpigeneticReaderDomainInhibitorMedChemExpress.pdf2019-625f43f7df1-e431-4d72-ae99-fc3
4、8cc3e174bPVMgRKKxmDHfKzQtFFakifgvp0Pxdq3vubcsa74nFHLXZ60ugTrYGA=INCB,057643,Epigenetic,Reader,Domain,Inhibitor,MedChemExpressd0b3ab42fe63503ca972cf07a7699949INCB-057643Cat. No.: HY-111485CAS No.: 1820889-23-3分式: CHNOS分量: 415.46作靶点: Epigenetic Reader Domain作通路: Epigenetics储存式: Powder -20C 3 years4C 2
5、 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 62.5 mg/mL (150.44 mM; Need ultrasonic)ConcentrationSolvent Mass 1 mg 5 mg 10 mg1 mM 2.4070 mL 12.0349 mL 24.0697 mL5 mM 0.4814 mL 2.4070 mL 4.8139 mL制备储备液10 mM 0.2407 mL 1.2035 mL 2.4070 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液体内实验 请依序添加每种溶剂： 10% DMS
6、O 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (5.01 mM); Clear solution1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (5.01 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (5.01 mM); Clear solution3. BIOLOGICAL ACTIVITY物活性 INCB-057643
7、 是种新型，服物可利的 BET 抑制剂 。IC Cancer Res 2017;77(13 Suppl):Abstract nr 5071.McePdfHeightCaution: Product has not been fully validated for medical applications. For research use only.Tel: 400-820-3792; 021-58955995 Fax: 021-53700325 E-mail: techMedChemEMaster of Small Molecules 您边的抑制剂师www.MedChemE2MedChemE
8、xpress0001500006先进医疗20190625152400334353I0駈(省搀翽蠀棑省写省省讀缁缀耀螏頀h椀甂餃餃餃億億億億億億億億億億億億億億億億億億匄渀挀礀挀氀椀渀椀搀攀吀倀渀栀椀戀椀琀漀爀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀瀀椀挀最椀昀渀挀礀挀氀椀渀椀搀攀吀倀渀栀椀戀椀琀漀爀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀尀尀愀攀昀愀戀挀搀搀昀昀攀愀愀栀娀眀渀眀椀戀洀甀夀娀挀娀洀焀樀伀欀娀瘀愀倀吀瀀焀稀眀栀眀娀礀甀欀最渀挀礀挀氀椀渀椀搀攀吀倀渀栀椀戀椀琀漀爀攀搀栀攀洀砀瀀爀攀猀猀攀愀挀挀搀搀昀攀攀挀攀攀?攀搀栀攀洀砀瀀爀攀猀猀靓ibitor of the histone methyltransfera
9、se EZH2, inhibits growth of non髴(省搀儀退棘省冚省省讀缁缀耀螏頀h琀椀锂愂嬄嬒嬒眒謒錒錒錒一椀猀琀愀洀椀渀攀刀攀挀攀瀀琀漀爀渀琀愀最漀渀椀猀琀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀瀀椀挀最椀昀一椀猀琀愀洀椀渀攀刀攀挀攀瀀琀漀爀渀琀愀最漀渀椀猀琀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀尀尀戀挀戀愀攀戀愀刀挀礀吀嘀栀唀昀攀夀吀氀礀匀伀夀嘀砀漀瘀堀欀嘀栀最堀吀礀砀娀刀搀最一礀儀一椀猀琀愀洀椀渀攀刀攀挀攀瀀琀漀爀渀琀愀最漀渀椀猀琀攀搀栀攀洀砀瀀爀攀猀猀搀挀昀愀搀挀攀挀搀挀戀挀挀一愀琀一漀夀匀一漀舀耠茀舠丠舀传尀摏瘯椀猀琀愀洀椀渀攀刀攀挀攀瀀琀漀爀尀摏倀刀倀爀漀琀攀椀渀洀洀甀渀漀氀漀最礀渀昀氀
10、愀洀洀愀琀椀漀渀塐倀漀眀搀攀爀礀攀愀爀猀礀攀愀爀猀渀猀漀氀瘀攀渀琀洀漀渀琀栀猀洀漀渀琀栀灠湥卣鹙豛匀伀洀最洀洀一攀攀搀甀氀琀爀愀猀漀渀椀挀漀渀挀攀渀琀爀愀琀椀漀渀匀漀氀瘀攀渀琀愀猀猀洀最洀最洀最洀洀洀洀洀洀洀洀洀洀洀洀湨葎蒐卭蕏鹑豛鶋轏匀伀最琀最琀匀椀渀猀愀氀椀渀攀匀漀氀甀戀椀氀椀琀礀攀洀最洀洀氀攀愀爀猀漀氀甀琀椀漀渀鶋轏匀伀最琀最琀挀漀爀渀漀椀氀匀漀氀甀戀椀氀椀琀礀攀洀最洀洀氀攀愀爀猀漀氀甀琀椀漀渀鶋轏匀伀最琀最琀倀最琀最琀吀眀攀攀渀最琀最琀猀愀氀椀渀攀匀漀氀甀戀椀氀椀琀礀攀洀最洀洀氀攀愀爀猀漀氀甀琀椀漀渀伀伀吀嘀吀夀挀椯一卓葠面盿谯笯卓葏瀀椀蔀耠渀一洀最欀最渀愀渀椀洀愀氀猀最爀漀甀瀀漀爀愀
11、洀瀀栀攀琀愀洀椀渀攀洀最欀最渀吀攀猀琀椀渀最椀猀椀洀洀攀搀椀愀琀攀氀礀爀攀猀甀洀攀搀昀漀氀氀漀眀椀渀最琀栀攀挀漀洀瀀漀甀渀搀椀渀樀攀挀琀椀漀渀嬀崀栀愀猀渀漀琀椀渀搀攀瀀攀渀搀攀渀琀氀礀挀漀渀昀椀爀洀攀搀琀栀攀愀挀挀甀爀愀挀礀漀昀琀栀攀猀攀洀攀琀栀漀搀猀吀栀攀礀愀爀攀昀漀爀爀攀昀攀爀攀渀挀攀漀渀氀礀刀刀一匀嬀崀愀爀戀椀攀爀攀琀愀氀挀甀琀攀眀愀欀攀瀀爀漀洀漀琀椀渀最愀挀琀椀漀渀猀漀昀一愀渀漀瘀攀氀搀椀愀洀椀渀攀戀愀猀攀搀愀渀琀愀最漀渀椀猀琀爀倀栀愀爀洀愀挀漀氀一漀瘀嬀崀戀甀栀愀洀搀愀栀刀攀琀愀氀昀昀攀挀琀猀漀昀洀攀琀栀椀洀攀瀀椀瀀愀渀搀一椀渀圀椀猀琀愀爀爀愀琀猀攀砀瀀漀猀攀搀琀漀愀渀漀瀀攀渀昀椀攀
12、氀搀眀椀琀栀愀渀搀眀椀琀栀漀甀琀漀戀樀攀挀琀愀渀搀椀渀愀氀戀挀洀椀挀攀攀砀瀀漀猀攀搀琀漀愀爀愀搀椀愀氀愀爀洀洀愀稀攀爀漀渀琀匀礀猀琀一攀甀爀漀猀挀椀甀氀挀攀倀搀昀攀椀最栀琀愀甀琀椀漀渀倀爀漀搀甀挀琀栀愀猀渀漀琀戀攀攀渀昀甀氀氀礀瘀愀氀椀搀愀琀攀搀昀漀爀洀攀搀椀挀愀氀愀瀀瀀氀椀挀愀琀椀漀渀猀漀爀爀攀猀攀愀爀挀栀甀猀攀漀渀氀礀吀攀氀愀砀洀愀椀氀琀攀挀栀攀搀栀攀洀砀瀀爀攀猀猀挀渀愀猀琀攀爀漀昀匀洀愀氀氀漀氀攀挀甀氀攀猀鵠蒏酶睞眀眀攀搀栀攀洀砀瀀爀攀猀猀挀渀攀搀栀攀洀砀瀀爀攀猀猀靓栁言茀渀7农省旵:鄀鰠胔-)輀/棙i缀$JNJ-61432059-iGluR-Modulator-MedChemExpre
13、ss.pdfpic1.gifJNJ61432059iGluRModulatorMedChemExpress.pdf2019-625cffa7b60-62eb-4fe1-960c-5817097ea313jfCdjGpm/JepwZyoyzTGpiqZKMsqoarBsKjeEf4NZ4YU5jaYXkzSxA=JNJ,61432059,iGluR,Modulator,MedChemExpress11546fcd5db55925683dc8820418cb8dJNJ-61432059Cat. No.: HY-111751CAS No.: 2035814-50-5分式: CHFNO分量: 443.
14、47作靶点: iGluR作通路: Membrane Transporter/Ion Channel; Neuronal Signaling储存式: Please store the product under the recommended conditions in the COA.BIOLOGICAL ACTIVITY物活性 JNJ-61432059 是具有服活性的、选择性的 AMPAR 的负向调节剂，其对 GluA1/-8 的 pIC50 值为9.7 。 在的海马体中显出具有时间和剂量依赖性的 AMPA 受体占情况，在膜点燃癫痫动物模型中显出较强的保护作 。IC 10(3):267-27
15、2.McePdfHeightCaution: Product has not been fully validated for medical applications. For research use only.Tel: 400-820-3792; 021-58955995 Fax: 021-53700325 E-mail: techMedChemEMaster of Small Molecules 您边的抑制剂师Product Data Sheet InhibitorsAgonistsScreening Librarieswww.MedChemE1MedChemExpress000150
16、0006先进医疗20190625152402819353Jure. The doses of TDZD-8 chosen are based on previous studies where doses ranging from 1 to 10 mg/kg reduced inflammation and tissue injury as well as improve psychiatric conditions.MCE has not independently confirmed the accuracy of these methods. They are for reference only.REFERENCES1. Bhowmik M, et al. Histamine H3 receptor antagonism by ABT-239 attenuates
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