1、Y-27632 dihydrochlorideCat. No.: HY-10583CAS No.: 129830-38-2分式: CHClNO分量: 320.26作靶点: ROCK作通路: Cell Cycle/DNA Damage; Stem Cell/Wnt; TGF-beta/Smad储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 H2O : 124 mg/mL (387.19 mM)DMSO : 32 mg/mL (99.92 mM)* “ means soluble, bu
2、t saturation unknown.ConcentrationSolvent Mass 1 mg 5 mg 10 mg1 mM 3.1225 mL 15.6123 mL 31.2246 mL5 mM 0.6245 mL 3.1225 mL 6.2449 mL制备储备液10 mM 0.3122 mL 1.5612 mL 3.1225 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液BIOLOGICAL ACTIVITY物活性 Y-27632 dihydrochloride 是 ATP 竞争性的 ROCK-I 和 ROCK-II 抑制剂， Ki 分别为 220 nM 和 300
3、nM，Y-27632 dihydrochloride 通过上-间充质过渡样调节引发诱导多能细胞 ( hIPSCs) 选择性地分化为间胚层谱系 。IC (2) S-Y (injection of saline i.p. and oral administration of Y27632); (3) DMN-S (DMN i.p. and oral administration of saline); (4) DMN-Y (DMN i.p. and oral administration of Y27632). The rats are weighed every week. They are s
4、acrificed at the end of the fourth week and the liver is excised. In addition, a blood sample is taken immediately before the rats are sacrificed.Animal Administration 34www.MedChemE2MCE has not independently confirmed the accuracy of these methods. They are for reference only.客户使本产品发表的科研献See more c
5、ustomer validations on www.MedChemEREFERENCES1. Ishizaki T, et al. Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases. Mol Pharmacol. 2000 May;57(5):976-83.2. Xue ZW, et al. Rho-associated coiled kinase inhibitor Y-27632 promotes neuronal-like differentiation of ad
6、ult human adipose tissue-derived stem cells.Chin Med J (Engl). 2012 Sep;125(18):3332-5.3. Inan S, et al. Antiepileptic effects of two Rho-kinase inhibitors, Y-27632 and fasudil, in mice. Br J Pharmacol. 2008 Sep;155(1):44-51.4. Tada S, et al. A selective ROCK inhibitor, Y27632, prevents dimethylnitr
7、osamine-induced hepatic fibrosis in rats. J Hepatol. 2001 Apr;34(4):529-36.5. Maldonado M, et al. ROCK inhibitor primes human induced pluripotent stem cells to selectively differentiate towardsmesendodermal lineage via epithelial-mesenchymal transition-like modulation. Stem Cell Res. 2016 Sep;17(2):
8、222-227.McePdfHeightCaution: Product has not been fully validated for medical applications. For research use only.Tel: 400-820-3792; 021-58955995 Fax: 021-53700325 E-mail: techMedChemEMaster of Small Molecules 您边的抑制剂师 Cell Rep. 2019 Jan 8;26(2):407-414.e5. Cancer Lett. 2019 Apr 28;448:117-127. J Exp Clin Cancer Res. 2018 Jun 28;37(1):128. Anal Chem. 2017 Oct 17;89(20):10841-10849. Stem Cell Res Ther. 2019 May 31;10(1):155.www.MedChemE3
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