1、KCA 757Cat. No.: HY-14938CAS No.: 125961-82-2Molecular Formula: CHOSMolecular Weight: 530.67Target: Leukotriene ReceptorPathway: GPCR/G ProteinStorage: Please store the product under the recommended conditions in the COA.Solvent LTE4, pA2: 6.45 (In guinea-pigs)In Vitro KCA757 inhibits the binding of
2、 3H LTD4 to the LTD4 receptors on pul-monary cell membrane of guinea-pigs (IC50 = 2.3 mol)2.In Vivo Fiftheen min after an aerosolized antigen challenge, and UNDW inhaled 5 min later into the guinea pigs, KCA-757 significantly alters the UNDW-induced bronchoconstriction1. KCA757 (1 and 5 mg/kg) admin
3、istered intravenously 15 min after antigen challenge reduces the propranolol-induced bronchoconstriction (PIB) in a dose-dependent manner in guinea-pigs2.REFERENCESProduct Data Sheet InhibitorsAgonistsScreening Librarieswww.MedChemE11. Fujimura M, et al. No involvement of lipid mediators in a guinea
4、 pig model of ultrasonically nebulized distilled water-induced bronchoconstriction. Prostaglandins Other Lipid Mediat. 2000 Jan;60(1-3):49-58.2. Fujimura M, et al. Role of leukotrienes in post-allergic propranolol-induced bronchoconstriction in guinea-pigs. Clin Exp Allergy. 1997 Oct;27(10):1219-26.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: techMedChemEAddress: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USAwww.MedChemE2