BX341-DataSheet-MedChemExpress.pdf
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1、BX341Cat. No.: HY-U00229CAS No.: 34633-34-6Molecular Formula: CHFOMolecular Weight: 292.32Target: Androgen ReceptorPathway: OthersStorage: Please store the product under the recommended conditions in the COA.Solvent BX341is readily absorbed following oral administration, but blood concentrations of
2、BX341 are low due to hepatic uptake and biliary excretion. After intravenous administration of 3H BX341 to rats (200 g/kg) and ferrets (60 g/kg) the blood concentrations of 3H decreases rapidly for the first 2 to 3 h, with the decrease being more rapid in females ( 18 min for rat, 30 min for ferret)
3、 than males (1.0 h for rat, 1.4 h for ferret). This is followed by a much slower decline (40 h for rat, 20 h for ferret) to concentrations at 96 h of less than 15 ng BX341 equivalents mL-1 (rat) or 1 ng BX341 equivalents mL-1 (ferret)1.PROTOCOLProduct Data Sheet InhibitorsAgonistsScreening Libraries
4、www.MedChemE1Animal Administration 1Mice, Rats, Dogs and Ferrets1 Swiss albino mice (24-28 g, males age 4 weeks, females age 6 weeks; pregnant mice mated at 6 weeks, used at day 18 of pregnancy) and Wistar albino rats (200 g males age 6 weeks, females age 8 weeks; 350 g males age 10 weeks) are fed D
5、ixons mouse and rat diet and have free access to water. Albino ferrets (0.7-2.6 kg, age 9-15 months) are fed raw meat, bread and milk. Male beagles (10.8-12.3 kg, age 10-14 years) are fed Spratts complete dog diet. 3H BX341 administration is by intragastric intubation, in propylene glycol (mouse 0.1
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