Lasmiditan-DataSheet-MedChemExpress.pdf
《Lasmiditan-DataSheet-MedChemExpress.pdf》由会员分享,可在线阅读,更多相关《Lasmiditan-DataSheet-MedChemExpress.pdf(2页珍藏版)》请在文库网上搜索。
1、LasmiditanCat. No.: HY-14861CAS No.: 439239-90-4Molecular Formula: CHFNOMolecular Weight: 377.36Target: 5-HT ReceptorPathway: GPCR/G Protein; Neuronal SignalingStorage: Please store the product under the recommended conditions in the COA.Solvent LY573144) is a high-affinity, highly selective 5-HT1F
2、receptor agonist(Ki=2.1 nM), compared with Ki of 1043 nM and 1357 nM at the 5-HT(1B) and 5-HT(1D) receptors, respectively.IC50 value: 2.1 nM (Ki, 5-HT1F); 1000 nM (Ki, 5-HT1B/5-HT1D) 1Target: 5-HT1F receptorin vitro: In vitro binding studies Lasmiditan showed a K(i) value of 2.21 nM at the 5-HT(1F)
3、receptor, compared with K(i) values of 1043 nM and 1357 nM at the 5-HT(1B) and 5-HT(1D) receptors, respectively, a selectivity ratio greater than 470-fold. Lasmiditan showed higher selectivity for the 5-HT(1F) receptor relative to other 5-HT(1) receptor subtypes than the first generation 5-HT(1F) re
4、ceptor agonist LY334370. Unlike the 5-HT(1B/1D) receptor agonist sumatriptan, lasmiditan did not contract rabbit saphenous vein rings, a surrogate assay for human coronary artery constriction, at concentrations up to 100 M 1.in vivo: In two rodent models of migraine, oral administration of lasmidita
- 配套讲稿:
如PPT文件的首页显示word图标,表示该PPT已包含配套word讲稿。双击word图标可打开word文档。
- 特殊限制:
部分文档作品中含有的国旗、国徽等图片,仅作为作品整体效果示例展示,禁止商用。设计者仅对作品中独创性部分享有著作权。
- 关 键 词:
- Lasmiditan DataSheet MedChemExpress