Lasmiditan-hydrochloride-DataSheet-MedChemExpress.pdf
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1、Lasmiditan hydrochlorideCat. No.: HY-14861ACAS No.: 613677-28-4Molecular Formula: CHClFNOMolecular Weight: 413.82Target: 5-HT ReceptorPathway: GPCR/G Protein; Neuronal SignalingStorage: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 monthSolvent 1000 nM (Ki, 5-HT1B/5-HT1D) 1Target: 5-HT
2、1F receptorin vitro: In vitro binding studies Lasmiditan showed a K(i) value of 2.21 nM at the 5-HT(1F) receptor, compared with K(i) values of 1043 nM and 1357 nM at the 5-HT(1B) and 5-HT(1D) receptors, respectively, a selectivity ratio greater than 470-fold. Lasmiditan show higher selectivity for t
3、he 5-HT(1F) receptor relative to other 5-HT(1) receptor subtypes than the first generation 5-HT(1F) receptor agonist LY334370. Unlike the 5-HT(1B/1D) receptor agonist sumatriptan, lasmiditan did not contract rabbit saphenous vein rings, a surrogate assay for human coronary artery constriction, at co
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- Lasmiditan hydrochloride DataSheet MedChemExpress
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