GBR-12935-dihydrochloride-DataSheet-MedChemExpress.pdf
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1、GBR 12935 dihydrochlorideCat. No.: HY-12242CAS No.: 67469-81-2Molecular Formula: CHClNOMolecular Weight: 487.5Target: Dopamine TransporterPathway: Neuronal SignalingStorage: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 monthSolvent Need ultrasonic and warming)ConcentrationSolvent Mass
2、 1 mg 5 mg 10 mg1 mM 2.0513 mL 10.2564 mL 20.5128 mL5 mM 0.4103 mL 2.0513 mL 4.1026 mLPreparing Stock Solutions10 mM 0.2051 mL 1.0256 mL 2.0513 mLPlease refer to the solubility information to select the appropriate solvent.BIOLOGICAL ACTIVITYDescription GBR 12935 2Hcl is a potent, and selective dopa
3、mine reuptake inhibitor.IC50 value: Target: dopamine reuptake inhibitorin vitro: The calculated Kd of 3HGBR-12935 binding to CYP2D6 was 42.2 nM, indicating that GBR-12935 has a high affinity for CYP2D6. The binding of 3HGBR-12935 to CYP2D6 was decreased partially by substrates or inhibitors of CYP2D
4、 isoforms (quinine, quinidine, propranolol, bufuralol, imipramine, and desipramine) 1. Co-perfusion of 100 microM GBR 12909 or GBR 12935 with either 100 microM sulpiride or raclopride produced a significant reduction in the GBR 12909 or GBR 12935 induced increase in the extracellular levels of dopam
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- GBR 12935 dihydrochloride DataSheet MedChemExpress
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