FK-3311-DataSheet-MedChemExpress.pdf
《FK-3311-DataSheet-MedChemExpress.pdf》由会员分享,可在线阅读,更多相关《FK-3311-DataSheet-MedChemExpress.pdf(2页珍藏版)》请在文库网上搜索。
1、FK 3311Cat. No.: HY-14445CAS No.: 116686-15-8Molecular Formula: CHFNOSMolecular Weight: 341.33Target: COXPathway: Immunology/InflammationStorage: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 monthSolvent antiinflammatory agent.IC50 Value: 1.6 uM 1Target: COX-2Cyclooxygenase (COX) is a
2、n intracellular enzyme that converts arachidonic acid into prostaglandin (PG)G2 and PGH2.in vitro: The racemic mixtures and the (R)- and (S)-isomers of the 2 metabolites were inactive in the PGE2 test. IC50 values were more than 100 uM for (2 and 5), compared to 1.6 uM for FK-3311. Antiinflammatory
3、activity was assessed by inhibition of adjuvant-induced arthritis, and analgesic activity was determined in the acetic acid-induced writhing assay. Following p.o. administration of 10 mg/kg, racemic (2) and its optical isomers showed activity comparable to FK-3311 (76% inhibition) in the adjuvant ar
4、thritis test, whereas racemic (5) showed very weak activity, and (R)- and (S)-(5) were not tested. With regard to analgesic effects, FK-3311 and racemic (2) showed 81 and 62% inhibitions, respectively, at a dose of 100 mg/kg p.o. The (R)- and (S)-isomers of (2) and racemic (5) all showed 46% inhibit
5、ion of writhing syndrome. (R)- and (S)-(5) were less active showing 16 and 20% inhibitions, respectively1.in vivo: L-PVR, CO, PaO(2), and WDR were significantly (P 0.05) better in the FK group than in the control group. Histological tissue edema was mild, and PMN infiltration was significantly (P 0.
- 配套讲稿:
如PPT文件的首页显示word图标,表示该PPT已包含配套word讲稿。双击word图标可打开word文档。
- 特殊限制:
部分文档作品中含有的国旗、国徽等图片,仅作为作品整体效果示例展示,禁止商用。设计者仅对作品中独创性部分享有著作权。
- 关 键 词:
- FK 3311 DataSheet MedChemExpress