氟哌噻吨美利曲辛片联合雷贝拉唑治疗上腹痛综合征的效果分析.pdf
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1、119中国现代药物应用2023年9月第17卷第18期Chin J Mod Drug Appl,Sep 2023,Vol.17,No.18氟哌噻吨美利曲辛片联合雷贝拉唑治疗上腹痛综合征的效果分析田金玲许微【摘要】目的研究氟哌噻吨美利曲辛片联合雷贝拉唑治疗上腹痛综合征的效果。方法133 例上腹痛综合征患者,根据随机数字编号方法分为观察组(66 例)和对照组(67 例)。对照组采用使用雷贝拉唑治疗,观察组采用氟哌噻吨美利曲辛片联合雷贝拉唑治疗。比较两组患者临床疗效、不良反应发生情况及治疗前后焦虑、抑郁心理。结果观察组治疗总有效率 95.45%显著高于对照组的 85.07%,差异有统计学意义(P0.0
2、5)。治疗后,两组汉密尔顿焦虑量表(HAMA)评分和汉密尔顿抑郁量表(HAMD)评分均低于本组治疗前,且观察组 HAMA 评分(4.630.90)分和 HAMD 评分(5.421.06)分均低于对照组的(5.220.99)、(6.12 1.17)分,差异有统计学意义(P0.05)。结论通过氟哌噻吨美利曲辛片联合雷贝拉唑对上腹综合征患者进行治疗,可以在确保安全的基础上提升临床疗效,改善患者的焦虑、抑郁心理,值得推荐。【关键词】氟哌噻吨美利曲辛片;雷贝拉唑;上腹痛综合征;疗效DOI:10.14164/11-5581/r.2023.18.033Effect analysis of flupentix
3、ol and melitracen tablets combined with rabeprazole in the treatment of epigastric pain syndrome TIAN Jin-ling,XU Wei.Department of Drug Distribution,Guangze County Hospital,Nanping 354100,China【Abstract】Objective To study the effect of flupentixol and melitracen tablets combined with rabeprazole in
4、 the treatment of epigastric pain syndrome.Methods A total of 133 patients with epigastric pain syndrome were divided into observation group(66 cases)and control group(67 cases)according to random number numbering method.The control group was treated with rabeprazole,and the observation group was tr
5、eated with flupentixol and melitracen tablets and rabeprazole.The clinical efficacy,occurrence of adverse reactions,anxiety and depression before and after treatment were compared between the two groups.Results The total effective rate of 95.45%in the observation group was significantly higher than
6、that of 85.07%in the control group,and the difference was statistically significant(P0.05).After treatment,the Hamilton Anxiety Scale(HAMA)score and Hamilton Depression Scale(HAMD)score in both groups were lower than those before treatment in this group;HAMA score of(4.630.90)points and HAMD score o
7、f(5.421.06)points in the observation group were lower than those of(5.220.99)and(6.12 1.17)points in the control group;the differences were statistically significant(P0.05),具有可比性。所有患者的资料均与世界医学会赫尔辛基宣言内容对照且符合,患者及其家属阅读入院须知,签署知情同意书。1.2纳入及排除标准1.2.1纳入标准患者入院后确诊为上腹痛综合征,满足罗马上腹痛综合征的标准;患者主要表现为上腹部灼烧感或上腹部疼痛,且每周至
8、少出现 1 次;患者 HAMA 评分 7 分,HAMD 评分 8 分;患者经大便潜血试验和常规检查、血液生化检验、胃镜和腹部超声检查等均未发现器质性病变;患者具有较高的治疗依从性,临床资料完整。1.2.2排除标准合并胆道、肝胆胰器质性病变;明确存在各种疾病导致的腹痛;严重肝肾综合征;3 个月内应用过镇静类药物或抗抑郁药物;对氟哌噻吨美利曲辛片、雷贝拉唑等药物不耐受或者过敏;患者依从性较低或者不愿意配合参与研究。1.3方法对照组患者使用雷贝拉唑治疗,10 mg/次,顿服。持续治疗 8 周。观察组患者使用氟哌塞顿美利曲辛片联合雷贝拉唑治疗,雷贝拉唑用法、用量与对照组一致;氟哌噻吨美利曲辛片 5 m
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