恶性孤立性肺结节患者电视胸腔镜手术治疗的预后情况及其影响因素分析.pdf
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1、it Solitary(调查统计)论著.1471.临床医学1程2 0 2 3年10 月第30 卷第10 期恶性孤立性肺结节患者电视胸腔镜手术治疗的预后情况及其影响因素分析乔鸿飞,马文杰,贾明选,郭亮(黄河三门峡医院心胸外科,河南三门峡47 2 0 0 0)【摘要】目的分析恶性孤立性肺结节(SPN)患者电视胸腔镜手术治疗的预后情况及其影响因素。方法15 0 例行电视胸腔镜手术治疗的恶性SPN患者术后随访2 年,统计生存与死亡情况。收集患者的临床资料,分析预后的影响因素。结果15 0 例恶性SPN患者随访期间死亡2 1例(14.0 0%)。死亡组的年龄、结节直径均显著大于生存组,家族史占比、吸烟史
2、占比、高血压病史占比、STK1水平及Ki-67阳性表达占比均显著高于生存组(P0.05)。C O X 多因素生存分析显示,年龄大、有吸烟史、血清STK1水平高、Ki-67阳性表达是恶性SPN患者电视胸腔镜手术治疗预后不良的危险因素(P0.05)。结论年龄大、有吸烟史、血清STK1水平高、Ki阳性表达会增加恶性SPN患者电视胸腔镜手术治疗的不良预后发生风险,临床应重点关注此类患者并开展相应的防治措施,以有效改善患者的预后。【关键词】恶性孤立性肺结节;电视胸腔镜手术;预后;影响因素中图分类号:R563文献标识码:Adoi:10.3969/j.issn.1674-4659.2023.10.1471A
3、nalysis on the Prognosis of Video-Assisted Thoracoscopic Surgery in the Treatment of Patients with MalignarPulmonary Nodules and Its Influencing Factors/QIAO Hongfei,MA Wenjie,JIA Mingxuan,GUO LiangPulmonary Nodules and Its Influencing Factors I/QIAO Hongfei,MA Wenjie,JIA Mingxuan,GUO Liang(Departme
4、nt of Cardiothoracic Surgery,Yellow River Sanmenxia Hospital,Sanmenxia 472000,China)AbstractObjective To analyze the prognosis of video-assisted thoracoscopic surgery in the treatment of patients with malignantsolitary pulmonary nodules(SNP)and its influencing factors.Methods 150 patients with malig
5、nant SPN who underwent video-assistedthoracoscopic surgery were followed-up for 2 years to count the survival and death cases.The clinical data of the patients were collected andthe influencing factors of prognosis were analyzed.Results During the follow-up period,21 of 150 patients with malignant S
6、PN died(14.00%).The age and nodule diameter of the death group were significantly bigger than those of the survival group,and the proportions offamily history,smoking history and hypertension history,STK1 level,and proportion of Ki-67 positive expression were significantly higherthan those in the su
7、rvival group(P0.05).COX multivariate survival analysis showed that older age,smoking history,high serum STK1level and positive expression of Ki-67 were risk factors for poor prognosis of video-assisted thoracoscopic surgery in patients with malignantSPN(P0.05).Conclusions Older age,smoking history,h
8、igh serum STK1 level and positive expression of Ki will increase the occurrencerisk of poor prognosis of patients with malignant SPN treated by video-assisted thoracoscopic surgery.Clinical attention should be paid tosuch patients and corresponding prevention and treatment measures should be carried
9、 out to effectively improve the prognosis of patients.Key wordsMalignant solitary pulmonary nodules;Video-assisted thoracoscopic surgery;Prognosis;Influencing factor0前言孤立性肺结节(solitary pulmonary nodules,S P N)是一种直径3cm且不具有典型影像学特征的结节性病变,肺腺癌、鳞癌等均为常见的恶性SPN病变,严重威胁患者生命健康,一经确诊需及时采取有效的治疗方案,以提高患者生存率。电视胸腔镜手术是目
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- 恶性 孤立 结节 患者 电视 胸腔镜 手术 治疗 预后 情况 及其 影响 因素 分析