富血小板血浆关节腔注射治疗类风湿关节炎的临床效果研究.pdf
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1、论著 临床医学JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH中外医药研究2023年第2卷第17期中外医药研究2023年第2卷第17期类风湿关节炎(RA)是以炎性滑膜炎为主的关节炎性疾病,症状以手足小关节的多关节、对称性、侵袭性关节炎性反应为主,严重者可导致关节畸形、功能丧失,可伴有关节外器官受累及血清类风湿因子阳性。RA的治疗以减轻关节炎性反应、抑制病变发展至不可逆的骨质破坏为主要原则,多采用非甾体抗炎药、抗风湿药、糖皮质激素等药物进行病情控制。部分患者经口服药物治疗效果不佳或病情持续进展,需寻找其他高效治疗策略以优化
2、患者的整体状态。富血小板血浆(PRP)是自体全血经离心后得到的血小板浓缩物,已在肌腱病、腰椎间盘源性神经痛、皮肤损伤等领域成功应用1-2。PRP修复肌腱、软骨等作用也适用于RA,故本文将超声引导下PRP关节腔注射引入RA患者的治疗,探讨其在RA治疗中的效果,为后续同类患者的治疗提供借鉴,报告如下。资料与方法选取 2021 年 1 月2022 年 9 月扬州大学附属医院收治的 RA 患者 176 例作为观察对象,根据随机数字表法分为对照组和观察组,各 88 例。观察组男48例,女40例;年龄4575岁,平均(60.587.84)岁;病程 14年,平均(2.211.05);体重指数(BMI)222
3、7kg/m2,平均(24.511.25)kg/m2。对照组男 47例,女 41例,年龄 4574岁,平均(61.627.79)岁;富血小板血浆关节腔注射治疗类风湿关节炎的临床效果研究庞雨冰李国青(通信作者)225000扬州大学附属医院风湿免疫科,江苏 扬州摘要目的:探讨富血小板血浆(PRP)关节腔注射治疗类风湿关节炎(RA)的临床效果。方法:选取2021年1月2022年9月扬州大学附属医院收治的RA患者176例作为观察对象,根据随机数字表法分为对照组和观察组,各88例。对照组给予甲氨蝶呤治疗,观察组在对照组基础上给予PRP关节腔注射治疗。比较两组患者疼痛程度、膝关节功能、炎性因子水平。结果:治
4、疗后,两组患者视觉模拟评分均降低,观察组低于对照组,差异有统计学意义(P0.001);治疗后,两组患者Lyshlom膝关节各维度评分均高于治疗前,观察组高于对照组,差异有统计学意义(P0.05);两组患者血清超敏C反应蛋白、白细胞介素-1、白细胞介素-6水平均低于治疗前,观察组低于对照组,差异有统计学意义(P0.001)。结论:PRP关节腔注射可有效减轻RA患者的患肢疼痛,优化膝关节功能,降低炎性水平。关键词类风湿关节炎;富血小板血浆;关节腔注射;膝关节功能;炎性反应Clinical Effect of Joint Cavity Injection of Platelet-rich Plasm
5、a in Treatment of Rheumatoid ArthritisPang Yubing,Li Guoqing(corresponding author)Department of Rheumatology and Immunology,the Affiliated Hospital of Yangzhou University,Yangzhou 225000,Jiangsu Province,ChinaAbstractObjective:To investigate the clinical effect of platelet-rich plasma(PRP)joint cavi
6、ty injection in the treatment ofrheumatoid arthritis(RA).Methods:A total of one hundred and seventy-six RA patients admitted to the Affiliated Hospital ofYangzhou University from January 2021 to September 2022 were selected as the observation objects,and were divided into controlgroup and observatio
7、n group according to random number table method,with eighty-eight cases in each group.The control groupwas treated with methotrexate,and the observation group was treated with PRP joint cavity injection based on the control group.Thepain degree,knee joint function and inflammatory factors were compa
8、red between the two groups.Results:After treatment,thevisual analog scores of both groups were decreased,and the observation group was lower than the control group,the difference wasstatistically significant(P0.001);After treatment,Lyshlom knee joint scores in 2 groups were higher than before treatm
9、ent,observation group was higher than control group,the difference was statistically significant(P0.05);Serum levels of hypersensitiveC-reactive protein,interleukin-1 and interleukin-6 in 2 groups were lower than before treatment,and observation group was lowerthan control group,the difference was s
10、tatistically significant(P0.001).Conclusion:PRP articular cavity injection can effectivelyreduce the pain of the affected limb in RA patients,optimize the function of the knee joint,and reduce the level of inflammation.Key wordsRheumatoid arthritis;Platelet-rich plasma;Articular cavity injection;Kne
11、e joint function;Inflammatory response48论著 临床医学JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH中外医药研究2023年第2卷第17期中外医药研究2023年第2卷第17期病程14年,平均(2.241.03)年;BMI 2227kg/m2,平均(24.351.27)kg/m2。两组临床资料比较,差异无统计学意义(P0.05),具有可比性。患者及家属知情同意本研究,签署知情同意书。纳入标准:符合1987年RA分类标准3-4;认知功能正常,可进行围术期正常沟通交流;临床资料完整。排除
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- 关 键 词:
- 血小板 血浆 关节 注射 治疗 类风湿 关节炎 临床 效果 研究