丁苯酞联合法舒地尔治疗急性脑梗死的疗效观察.pdf
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1、Sichuan Journal of Anatomy2023,31(3):36-38论著四川解剖学杂志丁苯酰联合法舒地尔治疗急性脑梗死的疗效观察肖成成,祝孔辉1.信阳市中心医院药学科,信阳46 40 9 9;2.信阳市中心医院神经重症监护病区,信阳46 40 9 9【摘要】目的:探讨丁苯酞联合法舒地尔治疗急性脑梗死(ACI)的临床效果。方法:选取2 0 2 0 年5月至2 0 2 2 年6月本院收治的8 0 例ACI患者,按随机对照原则将其分为观察组(n=40,丁苯酞联合法舒地尔治疗)和对照组(n=40,仅给予法舒地尔治疗)。治疗14d后,比较两组患者的临床疗效、日常生活能力、神经缺损程度及血
2、清指标。结果:观察组的治疗总有效率为9 5.0 0%(38/40),高于对照组8 0.0 0%(32/40),差异有统计学意义(P 0.0 5);治疗后,两组美国国立卫生研究院卒中量表(NIHSS)评分均下降,巴塞尔指数(BI)均上升,差异均有统计学意义(P0.05);治疗后,两组基质金属蛋白酶2(MMP-2)、基质金属蛋白酶9(MMP-9)水平均降低,且观察组水平较对照组低,差异均有统计学意义(P0.05)。结论:丁苯酞联合法舒地尔治疗ACI可提升疗效,改善MMP-2、M M P-9 水平,减轻神经损伤程度,改善患者日常生活质量。【关键词】急性脑梗死;丁苯酞;法舒地尔;日常生活能力;神经缺损
3、程度D0I:10.3969/j.issn.1005-1457.2023.03.012Observation on the Therapeutic Effect of Butylphthalide Combined with Fasudilin the Treatment of Acute Cerebral InfarctionXIAO Cheng-cheng,ZHU Kong-hui?1.Pharmacy Department of Xinyang Central Hospital,Xinyang 464099,China;2.Neurological Intensive Care Ward,
4、Xinyang CentralHospital,Xinyang 464099,ChinaCorrespondence:XIA0 Cheng-cheng,e-Mail:wjzfsz Abstract】O b j e c t i v e:T o e x p l o r e t h e c l i n i c a l e f f e c t o f b u t y l p h t h a l i d e c o mb i n e d w i t h f a s u d i l i n t h e t r e a t me n t o f a c u t ecerebral infarction(AC
5、I).Methods:A total of 80 ACI patients admitted to the hospital from May 2020 to June 2022 wereselected and divided into observation group(n=40)and control group(n=40)according to the principle of randomizedcontrol.The observation group was treated with intravenous infusion of butylphthalide sodium c
6、hloride injection and fasudilhydrochloride injection,while the control group was only treated with fasudil hydrochloride injection.After 14 days oftreatment,the clinical efficacy,daily living ability,degree of neurological impairment,and serum indicators werecompared between two groups.Results:The t
7、otal effective rate of 95.0%in the observation group was higher than 80.00%in the control group(P0.05).After treatment,both both National Institute of Health stroke scale(NIHSS)decreasedand Barthelindex(BI)scores increased in both groups,with a statistically significant difference(P 0.05).Aftertreat
8、ment,the levels of matrix metalloproteinase(MMP)-2,and MMP-9 in both groups decreased on average,and thelevels in the observation group were lower than those in the control group,with a statistically significant difference(P 0.05)2方法观察组接受法舒地尔联合丁苯酞治疗。法舒地尔用法:每次取30 mg盐酸法舒地尔(湖北日升昌新材料科技有限公司,规格:2 mL:30 m
9、g)静脉滴注,2 次/dx2w。丁苯酞使用方法:取2 5mg丁苯酞(石药集团恩必普药业有限公司,规格:10 0 mL:25mg)静脉滴注,1次/dx2w。对照组仅给予法舒地尔治疗,用法用量及治疗时间均同观察组。3观察指标3.1临床疗效于治疗2 周后评估疗效。显效:神经功能缺损下降幅度45%9 0%;有效:神经功能缺损下降幅度18%45%;无效:神经功能缺损下降幅度 18%。总有效率(%)=(显效例数+有效例数)/总例数10 0%。3.2日常生活能力和神经缺损程度于治疗前、治疗后分别通过Barthel 指数量表(Ba r t h e l i n d e x,BI)和美国国立卫生研究院卒中量表(N
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- 丁苯酞 联合 治疗 急性 脑梗死 疗效 观察